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dc.contributor.author
Gonzalez, Candela Rocio
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dc.contributor.author
Calandra, Ricardo Saul
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dc.contributor.author
Gonzalez Calvar, Silvia Ines
dc.date.available
2016-05-05T19:05:56Z
dc.date.issued
2013-10-30
dc.identifier.citation
Gonzalez, Candela Rocio; Calandra, Ricardo Saul; Gonzalez Calvar, Silvia Ines; Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation; Scientific Research; Advances in Bioscience and Biotechnology; 4; 10C; 30-10-2013; 1-7
dc.identifier.issn
2156-8456
dc.identifier.uri
http://hdl.handle.net/11336/5538
dc.description.abstract
Transforming growth factor beta 1 (TGF-beta1) is a key regulator that modulates male reproductive function. Testicular TGF-beta1 modulates the steroidogenesis of Leydig cells, the organization of peritubular myoid cells, testis development and spermatogenesis. Several studies have indicated that TGF-beta1 is involved in the tight balance between proliferative and apoptotic re- sponses in the Leydig cells. In the present review, we summarize the direct effects of this cytokine in Ley- dig cells under normal and pathological conditions. We analyze the effect of TGF-beta1 in Leydig cells de- pending on the type of receptors involved in the sig- naling pathway of TGF-beta1. Our group has been ana- lyzing the canonical and non canonical intracellular signaling pathways of TGF-beta1 that are involved in the expression of proliferative and apoptotic markers in Leydig cells. On the basis of our studies and from those of other authors we conclude that the balance between the expression of TGF-beta1 receptors and co receptors is of relevance in Leydig cell physiology and pathophisiology.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Scientific Research
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Tgf-B1
dc.subject
Leydig
dc.subject
Alk
dc.subject
Endoglin
dc.subject.classification
Urología y Nefrología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-05-06 15:52:43.262787-03
dc.journal.volume
4
dc.journal.number
10C
dc.journal.pagination
1-7
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Delaware
dc.description.fil
Fil: Gonzalez, Candela Rocio. Universidad Maimonides. Area de Invest.biomedicas y Biotecnologicas; Argentina
dc.description.fil
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Gonzalez Calvar, Silvia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.journal.title
Advances in Bioscience and Biotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.4236/abb.2013.410A4001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.scirp.org/journal/PaperInformation.aspx?PaperID=36606
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4236/abb.2013.410A4001
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