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dc.contributor.author
de Nicola, Alejandro Federico
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Gonzalez Deniselle, Maria Claudia
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Garay, Laura Ines
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Meyer, Maria
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Gargiulo Monachelli, Gisella Mariana
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Guennoun, Rachida
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Schumacher, M.
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Carreras, Maria Cecilia
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Poderoso, Juan José
dc.date.available
2016-05-05T18:47:22Z
dc.date.issued
2013-10-28
dc.identifier.citation
de Nicola, Alejandro Federico; Gonzalez Deniselle, Maria Claudia; Garay, Laura Ines; Meyer, Maria; Gargiulo Monachelli, Gisella Mariana; et al.; Progesterone protective effects in neurodegeneration and neuroinflamation; Wiley; Journal of Neuroendocrinology; 25; 11; 28-10-2013; 1095-1103
dc.identifier.issn
0953-8194
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http://hdl.handle.net/11336/5535
dc.description.abstract
Progesterone is a neuroprotective, promyelinating and antiinflammatory factor for the nervous system. Here we discuss progesterone effects in models of motoneuron degeneration and neuroinflammation. In neurodegeneration of the Wobbler mouse, a subset of spinal cord motoneurons showed increased activity of nitric oxide synthase (NOS), increased intramitochondrial NOS, decreased activity of respiratory chain complexes and decreased activity and protein expression of Mnsuperoxide dismutase type 2 (MnSOD2). Clinically, Wobblers suffered several degrees of motor impairment. Progesterone treatment restored the expression of neuronal markers, decreased the activity of NOS and enhanced complex I respiratory activity and MnSOD2. Long-term treatment with progesterone increased muscle strength, biceps weight and survival. Collectively, these data supported that progesterone prevented neurodegeneration. To study progesterone effects in neuroinflammation, we employed mice with experimental autoimmune encephalomyelitis (EAE). EAE mice spinal cord showed increased mRNA levels of the inflammatory mediators tumour necrosis factor α (TNFα) and its receptor TNFR1, the microglial marker CD11b, iNOS and the toll-like receptor 4 (TLR4). Progesterone pretreatment of EAE mice blocked the proinflammatory mediators, decreased Iba1+ microglial cells and attenuated clinical signs of EAE. Therefore, reactive glial cells became targets of progesterone anti-inflammatory effects. These results open the ground for testing the usefulness of neuroactive steroids for neurological disorders.
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application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Progesterone
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Neuroprotection
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Wobbler Mouse
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Anti-Inflammatory Effects
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Experimental Autoimmune Encephalomyelitis
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Progesterone protective effects in neurodegeneration and neuroinflamation
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info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-05-06 15:52:43.262787-03
dc.identifier.eissn
1365-2826
dc.journal.volume
25
dc.journal.number
11
dc.journal.pagination
1095-1103
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.conicet.avisoEditorial
This is the peer reviewed version of the following article: de Nicola, Alejandro Federico; Gonzalez Deniselle, Maria Claudia; Garay, Laura Ines; Meyer, Maria; Gargiulo Monachelli, Gisella Mariana; et al.; Progesterone protective effects in neurodegeneration and neuroinflamation; Wiley; Journal of Neuroendocrinology; 25; 11; 28-10-2013; 1095-1103, which has been published in final form at DOI: 10.1111/jne.12043. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
dc.description.fil
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
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Fil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
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Fil: Garay, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
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Fil: Meyer, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
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Fil: Gargiulo Monachelli, Gisella Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
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Fil: Guennoun, Rachida. Inserm; Francia. Universite Paris Sud; Francia
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Fil: Schumacher, M.. Inserm; Francia. Universite Paris Sud; Francia
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Fil: Carreras, Maria Cecilia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina
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Fil: Poderoso, Juan José. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.journal.title
Journal of Neuroendocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/23639063
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info:eu-repo/semantics/altIdentifier/doi/10.1111/jne.12043
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info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/jne.12043/abstract
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jne.12043
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