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dc.contributor.author
Camerano, Gabriela Veronica
dc.contributor.author
Bustuoabad, Oscar David
dc.contributor.author
Meiss, Roberto Pablo
dc.contributor.author
Gómez, Sonia Alejandra
dc.contributor.author
Fernández, Gabriela Cristina
dc.contributor.author
Isturiz, Martín Amadeo
dc.contributor.author
Palermo, Marina Sandra
dc.contributor.author
Dran, Graciela Isabel
dc.date.available
2018-08-14T01:05:57Z
dc.date.issued
2006-05
dc.identifier.citation
Camerano, Gabriela Veronica; Bustuoabad, Oscar David; Meiss, Roberto Pablo; Gómez, Sonia Alejandra; Fernández, Gabriela Cristina; et al.; Compensatory renal growth protects mice against Shiga toxin 2-induced toxicity; Springer Verlag Berlín; Pediatric Nephrology; 21; 8; 5-2006; 1082-1092
dc.identifier.issn
0931-041X
dc.identifier.uri
http://hdl.handle.net/11336/55315
dc.description.abstract
Uninephrectomy (Unx) is followed by the compensatory renal growth (CRG) of the remaining kidney. Previous evidence has shown that during CRG, renal tissue is resistant to a variety of pathologies. We tested the hypothesis that the functional changes that take place during CRG could attenuate Shiga toxin (Stx) toxicity in a mouse model of Stx2-induced hemolytic uremic syndrome (HUS). The participation of nitric oxide (NO) was analyzed. After CRG induction with Unx, mice were exposed to a lethal dose of Stx2, and the degree of renal damage and mortality was measured. Stx2 effects on the growth, renal blood flow (RBF) and NO synthase (NOS) intrarenal expression in the remaining kidney were then studied. The induction of CRG strongly prevented Stx2-mediated mortality and renal damage. Administration of the NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME) during CRG partially impaired the protection. Both Stx2 and L-NAME interfered with the hypertrophic and hyperplastic responses to Unx, as well as with the increase in RBF. In intact mice, Stx2 decreased renal perfusion, inhibited endothelial NOS basal expression and enhanced inducible NOS expression; all of these effects were attenuated by prior Unx. It is concluded that during CRG mice are highly protected against Stx2 toxicity and lethality. The protective capacity of CRG could be related to the enhancement of renal perfusion and preservation of eNOS renal expression, counterbalancing two major pathogenic mechanisms of Stx2.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Verlag Berlín
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Compensatory Renal Growth
dc.subject
Hemolytic Uremic Syndrome
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Shiga Toxin
dc.subject
Uninephrectomy
dc.subject.classification
Inmunología
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Compensatory renal growth protects mice against Shiga toxin 2-induced toxicity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-13T19:01:04Z
dc.identifier.eissn
1432-198X
dc.journal.volume
21
dc.journal.number
8
dc.journal.pagination
1082-1092
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Camerano, Gabriela Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Bustuoabad, Oscar David. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Meiss, Roberto Pablo. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Gómez, Sonia Alejandra. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Fernández, Gabriela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Isturiz, Martín Amadeo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Palermo, Marina Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Dran, Graciela Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
Pediatric Nephrology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00467-006-0115-5
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00467-006-0115-5


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