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dc.contributor.author Camerano, Gabriela Veronica
dc.contributor.author Bustuoabad, Oscar David
dc.contributor.author Meiss, Roberto Pablo
dc.contributor.author Gómez, Sonia Alejandra
dc.contributor.author Fernández, Gabriela Cristina
dc.contributor.author Isturiz, Martín Amadeo
dc.contributor.author Palermo, Marina Sandra
dc.contributor.author Dran, Graciela Isabel
dc.date.available 2018-08-14T01:05:57Z
dc.date.issued 2006-05
dc.identifier.citation Camerano, Gabriela Veronica; Bustuoabad, Oscar David; Meiss, Roberto Pablo; Gómez, Sonia Alejandra; Fernández, Gabriela Cristina; et al.; Compensatory renal growth protects mice against Shiga toxin 2-induced toxicity; Springer Verlag Berlín; Pediatric Nephrology; 21; 8; 5-2006; 1082-1092
dc.identifier.issn 0931-041X
dc.identifier.uri http://hdl.handle.net/11336/55315
dc.description.abstract Uninephrectomy (Unx) is followed by the compensatory renal growth (CRG) of the remaining kidney. Previous evidence has shown that during CRG, renal tissue is resistant to a variety of pathologies. We tested the hypothesis that the functional changes that take place during CRG could attenuate Shiga toxin (Stx) toxicity in a mouse model of Stx2-induced hemolytic uremic syndrome (HUS). The participation of nitric oxide (NO) was analyzed. After CRG induction with Unx, mice were exposed to a lethal dose of Stx2, and the degree of renal damage and mortality was measured. Stx2 effects on the growth, renal blood flow (RBF) and NO synthase (NOS) intrarenal expression in the remaining kidney were then studied. The induction of CRG strongly prevented Stx2-mediated mortality and renal damage. Administration of the NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME) during CRG partially impaired the protection. Both Stx2 and L-NAME interfered with the hypertrophic and hyperplastic responses to Unx, as well as with the increase in RBF. In intact mice, Stx2 decreased renal perfusion, inhibited endothelial NOS basal expression and enhanced inducible NOS expression; all of these effects were attenuated by prior Unx. It is concluded that during CRG mice are highly protected against Stx2 toxicity and lethality. The protective capacity of CRG could be related to the enhancement of renal perfusion and preservation of eNOS renal expression, counterbalancing two major pathogenic mechanisms of Stx2.
dc.format application/pdf
dc.language.iso eng
dc.publisher Springer Verlag Berlín
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject COMPENSATORY RENAL GROWTH
dc.subject HEMOLYTIC UREMIC SYNDROME
dc.subject SHIGA TOXIN
dc.subject UNINEPHRECTOMY
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Compensatory renal growth protects mice against Shiga toxin 2-induced toxicity
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-08-13T19:01:04Z
dc.identifier.eissn 1432-198X
dc.journal.volume 21
dc.journal.number 8
dc.journal.pagination 1082-1092
dc.journal.pais Alemania
dc.journal.ciudad Berlin
dc.description.fil Fil: Camerano, Gabriela Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Bustuoabad, Oscar David. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Meiss, Roberto Pablo. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil Fil: Gómez, Sonia Alejandra. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil Fil: Fernández, Gabriela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Isturiz, Martín Amadeo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Palermo, Marina Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Dran, Graciela Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title Pediatric Nephrology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00467-006-0115-5
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00467-006-0115-5
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)