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dc.contributor.author D'Atri, Lina Paola
dc.contributor.author Malaver Marín, Elisa
dc.contributor.author Romaniuk, María Albertina
dc.contributor.author Pozner, Roberto Gabriel
dc.contributor.author Negrotto, Soledad
dc.contributor.author Schattner, Mirta Ana
dc.date.available 2018-08-13T19:14:37Z
dc.date.issued 1997-07
dc.identifier.citation D'Atri, Lina Paola; Malaver Marín, Elisa; Romaniuk, María Albertina; Pozner, Roberto Gabriel; Negrotto, Soledad; et al.; Nitric oxide: News from stem cells to platelets; Bentham Science Publishers; Current Medicinal Chemistry; 16; 4; 7-1997; 417-429
dc.identifier.issn 0929-8673
dc.identifier.uri http://hdl.handle.net/11336/55200
dc.description.abstract Nitric oxide (NO) is a diffusible, short-lived, diatomic free radical ubiquitously produced by mammalian cells. The generation of NO from L-arginine is enzymatically regulated by three different isoforms of NO synthases. The NO signaling pathway involves mainly the activation of soluble guanylyl cyclase to produce cyclic GMP (cGMP) as a second messenger and downstream mediator. In addition, the free radical activity of NO can cause cellular damage through a phenomenon known as nitrosative stress. NO is a pleiotropic biomodulator in several systems, including the cardiovascular, nervous and immune systems. In the hematopoietic system, NO is thought to be an autocrine or paracrine messenger but also an intracellular effector molecule. Megakaryopoiesis and subsequent thrombopoiesis occur through complex biologic steps that involve hematopoietic stem cell commitment to megakaryocytic lineage, megakaryocyte maturation and finally, platelet release. Here, we summarize the current knowledge regarding the role of exogenous and endogenous NO in hematopoietic stem cell biology, megakaryocyte development and platelet biogenesis as well as relevance of platelet-derived NO generation on platelet function. Dysregulation of NO synthesis has been observed in several diseases, and the evaluation of a series of pharmacological agents with the ability to modulate the NO/ cGMP pathway in platelets will also be discussed.
dc.format application/pdf
dc.language.iso eng
dc.publisher Bentham Science Publishers
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject APOPTOSIS
dc.subject CGMP
dc.subject MEGAKARYOCYTES
dc.subject NITRIC OXIDE
dc.subject NO-NSAID
dc.subject PLATELETS
dc.subject STATINS
dc.subject STEM CELLS
dc.subject.classification Medicina Critica y de Emergencia
dc.subject.classification Medicina Clínica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Nitric oxide: News from stem cells to platelets
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-08-08T14:04:25Z
dc.journal.volume 16
dc.journal.number 4
dc.journal.pagination 417-429
dc.journal.pais Estados Unidos
dc.description.fil Fil: D'Atri, Lina Paola. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex". Departamento de Hemostasia y Trombosis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Malaver Marín, Elisa. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex". Departamento de Hemostasia y Trombosis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Romaniuk, María Albertina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex". Departamento de Hemostasia y Trombosis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Pozner, Roberto Gabriel. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex". Departamento de Hemostasia y Trombosis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Negrotto, Soledad. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex". Departamento de Hemostasia y Trombosis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Schattner, Mirta Ana. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex". Departamento de Hemostasia y Trombosis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title Current Medicinal Chemistry
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/092986709787315513
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/68513/article
dc.conicet.fuente individual


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)