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dc.contributor.author
Fundia, Ariela Freya
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dc.contributor.author
Gorostiaga, Maria Alicia
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dc.contributor.author
Mudry, Marta Dolores
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dc.date.available
2018-08-13T17:25:34Z
dc.date.issued
2000-02
dc.identifier.citation
Fundia, Ariela Freya; Gorostiaga, Maria Alicia; Mudry, Marta Dolores; Expression of common fragile sites in two Ceboidea species: Saimiri boliviensis and Alouatta caraya (Primates: Platyrrhini); BioMed Central; Genetics Selection Evolution; 32; 1; 2-2000; 87-97
dc.identifier.issn
1297-9686
dc.identifier.uri
http://hdl.handle.net/11336/55141
dc.description.abstract
Fragile sites are points of preferential breakage that may be involved in chromosome rearrangements. Induction of common fragile sites (c-fra) and spontaneous breakage were analyzed in two New World Monkeys species: Saimiri boliviensis (SBO) and Alouatta caraya (ACA). Spontaneous chromosome aberrations were analyzed on untreated lymphocyte cultures with Brögger´s formula (1977). SBO presented a low level of spontaneous breakage, while higher frequencies were detected in ACA in which bands 1q23; 2q13 and 11q19 were significantly affected (p<0.01). The populational distribution of c-fra was analyzed by the Chi2 test in FUdR plus caffeine treated cultures. A total of 21 c-fra was identified in SBO and 24 in ACA. Fragile sites A1q33, B1p21, B4p14, C3q23 and C5q22 were identified in all analyzed SBO specimens. The most frequent c-fra identified in ACA specimens were 1q23, 1q31, 1q33, 2q22, 8q14, 12q31, 13q22, 14q15 and Xq22. Fragile sites A1q31, A1q33, B1q14, B3q13, B4q21 and Xq22 identified in SBO and 1q31, 1q33, 2q22, 4q21, 6q13, 13q22 and Xq22 from ACA were the most conserved sites. A low coincidence between the location of c-fra and that of heterochromatin and breakpoints involved in euchromatic rearrangements known for these genera, was established.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Chromosome Fragile Sites
dc.subject
Ceboidea, Primates Platyrrhini
dc.subject
Heterochromatin
dc.subject
Evolution
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Expression of common fragile sites in two Ceboidea species: Saimiri boliviensis and Alouatta caraya (Primates: Platyrrhini)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-08T14:48:21Z
dc.journal.volume
32
dc.journal.number
1
dc.journal.pagination
87-97
dc.journal.pais
Francia
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dc.journal.ciudad
París
dc.description.fil
Fil: Fundia, Ariela Freya. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
dc.description.fil
Fil: Gorostiaga, Maria Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Mudry, Marta Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
dc.journal.title
Genetics Selection Evolution
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1186/1297-9686-32-1-87
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://gsejournal.biomedcentral.com/articles/10.1186/1297-9686-32-1-87
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