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dc.contributor.author
Hodge, Deborah L.
dc.contributor.author
Reynolds, Della
dc.contributor.author
Cerban, Fabio Marcelo
dc.contributor.author
Correa, Silvia Graciela
dc.contributor.author
Baez, Natalia Soledad
dc.contributor.author
Young, Howard A.
dc.contributor.author
Rodriguez Galan, Maria Cecilia
dc.date.available
2018-08-10T16:38:55Z
dc.date.issued
2012-10
dc.identifier.citation
Hodge, Deborah L.; Reynolds, Della; Cerban, Fabio Marcelo; Correa, Silvia Graciela; Baez, Natalia Soledad; et al.; MCP-1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes; Wiley VCH Verlag; European Journal of Immunology; 42; 10; 10-2012; 2644-2654
dc.identifier.issn
0014-2980
dc.identifier.uri
http://hdl.handle.net/11336/54965
dc.description.abstract
Mature lymphocyte immigration into the thymus has been documented in mouse, rat, and pig models, and highly increases when cells acquire an activated phenotype. Entrance of peripheral B and T cells into the thymus has been described in healthy and pathological situations. However, it has not been proposed that leukocyte recirculation to the thymus could be a common feature occurring during the early phase of a Th1 inflammatory/infectious process when a large number of peripheral cells acquire an activated phenotype and the cellularity of the thymus is seriously compromised. The data we present here demonstrate that in well-established Th1 models triggered by different types of immunogens, for example, LPS treatment (a bacterial product), Candida albicans infection (a fungus), and after Trypanosoma cruzi infection (a parasite), a large number of mature peripheral B and T cells enter the thymus. This effect is dependent on, but not exclusive of, the available space in the thymus. Our data also demonstrate that MCP-1/CCR2 (where MCP-1 is monocyte chemoattractant protein-1) interaction is responsible for the infiltration of peripheral cells to the thymus in these Th1-inflammatory/infectious situations. Finally, systemic expression of IL-12 and IL-18 produced during the inflammatory process is ultimately responsible for these migratory events.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley VCH Verlag
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Il-12 And Il-18
dc.subject
Infection
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Mcp-1
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Peripheral B And T Cells
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Thymus Reentry
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Inmunología
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
MCP-1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-08T18:16:38Z
dc.identifier.eissn
2090-0031
dc.journal.volume
42
dc.journal.number
10
dc.journal.pagination
2644-2654
dc.journal.pais
Alemania
dc.journal.ciudad
Weinheim
dc.description.fil
Fil: Hodge, Deborah L.. Center for Cancer Research, Frederick National Laboratory for Cancer Research. Laboratory of Experimental Immunology, Cancer and Inflammation Program; Estados Unidos
dc.description.fil
Fil: Reynolds, Della. Center for Cancer Research, Frederick National Laboratory for Cancer Research. Laboratory of Experimental Immunology, Cancer and Inflammation Program; Estados Unidos
dc.description.fil
Fil: Cerban, Fabio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Correa, Silvia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Baez, Natalia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Young, Howard A.. Center for Cancer Research, Frederick National Laboratory for Cancer Research. Laboratory of Experimental Immunology, Cancer and Inflammation Program; Estados Unidos
dc.description.fil
Fil: Rodriguez Galan, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.journal.title
European Journal of Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201242408
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/eji.201242408
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/22740067/
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