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Artículo

Evaluation of constitutional chromosome aberrations in hematologic disorders

Cerretini, Roxana; Acevedo, Susana Haydee; Chena, Christian; Belli, Carolina BárbaraIcon ; Larripa, Irene BeatrizIcon ; Slavutsky, Irma RosaIcon
Fecha de publicación: 04/2002
Editorial: Elsevier Science Inc
Revista: Cancer Genetics And Cytogenetics
ISSN: 0165-4608
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

We have reviewed 4164 patients with various hematologic disorders cytogenetically studied in our laboratory during the last 25 years to analyze the frequency of constitutional chromosome aberrations (CCA) and to evaluate their association with hematologic malignancies. Our population of patients included 1133 pediatric patients and 3031 adults. Twenty-four (0.58%) cases showed CCA. They included four patients with Robertsonian translocations, one patient with a balanced translocation, two patients with sex chromosome abnormalities, and 17 cases with Down syndrome (DS). Nonsignificant differences among the frequency of patients with CCA from our hematologic series and those observed in the two largest combined surveys of livebirth published (0.65-0.84%) were found. The incidence of DS patients in our population (0.41%) was approximately three times higher than of that observed at birth (0.12-0.17%; P<0.001). The total incidence of constitutional chromosome abnormalities in the non-DS hematologic patients was 0.168% (7 of 4164) lower than of that observed in the newborn population (0.51-0.67%; P<0.001). Nonsignificant differences were found when the incidences of structural aberrations and sex chromosome anomalies were individually compared with the data of the overall population. Our results suggest that the presence of a CCA, other than DS, would not predispose patients to hematologic malignancies. © 2002 Elsevier Science Inc. All rights reserved.
Palabras clave: Chromosome Aberrations , Constitutional Alterations , Hematologic Disorders , Cytogenetics
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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URI: http://hdl.handle.net/11336/54827
DOI: https://dx.doi.org/10.1016/S0165-4608(01)00621-5
URL: https://www.sciencedirect.com/science/article/pii/S0165460801006215
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Citación
Cerretini, Roxana; Acevedo, Susana Haydee; Chena, Christian; Belli, Carolina Bárbara; Larripa, Irene Beatriz; et al.; Evaluation of constitutional chromosome aberrations in hematologic disorders; Elsevier Science Inc; Cancer Genetics And Cytogenetics; 134; 2; 4-2002; 133-137
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