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dc.contributor.author
Ponce, Nicolás Eric
dc.contributor.author
Cano, Roxana Carolina
dc.contributor.author
Carrera Silva, Eugenio Antonio
dc.contributor.author
Lima, Ana Paula
dc.contributor.author
Gea, Susana
dc.contributor.author
Aoki, Maria del Pilar
dc.date.available
2018-08-09T17:25:46Z
dc.date.issued
2012-05
dc.identifier.citation
Ponce, Nicolás Eric; Cano, Roxana Carolina; Carrera Silva, Eugenio Antonio; Lima, Ana Paula; Gea, Susana; et al.; Toll-like receptor-2 and interleukin-6 mediate cardiomyocyte protection from apoptosis during Trypanosoma cruzi murine infection; Springer; Medical Microbiology and Immunology; 201; 2; 5-2012; 145-155
dc.identifier.issn
0300-8584
dc.identifier.uri
http://hdl.handle.net/11336/54798
dc.description.abstract
Local innate immunity plays a key role in initiating and coordinating homeostatic and defense responses in the heart. We have previously reported that the cardiotropic parasite Trypanosoma cruzi, the etiological agent of Chagas disease, protects cardiomyocytes against growth factor deprivation-induced apoptosis. In this study, we investigated cardiomyocyte innate immune response to T. cruzi infection and its role in cellular protection from apoptosis. We found that Toll-like receptor (TLR) 2-expressing cellswere strongly increased by the parasite in BALB/c neonatal mouse cardiomyocyte cultures. Using a dominant-negative system, we showed that TLR2 mediated cardiomyocyte survival and the secretion of interleukin (IL) 6, which acted as an essential antiapoptotic factor. Moreover, IL6 released by infected cells, as well as the recombinant bioactive cytokine, induced the phosphorylation of the signal transducers and activators of transcription-3 (STAT3) in cultured cardiomyocytes. In accord with the in vitro results, during the acute phase of the infection, TLR2 expression increased 2.9-fold and the antiapoptotic factor Bcl-2 increased 4.5-fold in the cardiac tissue. We have clearly shown a cross-talk between the intrinsic innate response of cardiomyocytes and the pro-survival effect evoked by the parasite. © Springer-Verlag 2011.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Acute Infection
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Bcl-2
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Cardiomyocyte
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Heart Tissue
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Innate Immunity
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Interleukin-6
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Parasite Infection
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Stat3
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Survival
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Toll-Like Receptor-2
dc.subject.classification
Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Toll-like receptor-2 and interleukin-6 mediate cardiomyocyte protection from apoptosis during Trypanosoma cruzi murine infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-08T18:15:54Z
dc.identifier.eissn
1432-1831
dc.journal.volume
201
dc.journal.number
2
dc.journal.pagination
145-155
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Ponce, Nicolás Eric. Universidad Nacional de Cordoba. Facultad de Cs.quimicas. Departamento de Bioquimica Clinica. Cat.de Inmunologia; Argentina
dc.description.fil
Fil: Cano, Roxana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Carrera Silva, Eugenio Antonio. University of Yale; Estados Unidos
dc.description.fil
Fil: Lima, Ana Paula. Universidade Federal do Rio de Janeiro; Brasil
dc.description.fil
Fil: Gea, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Aoki, Maria del Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.journal.title
Medical Microbiology and Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.springerlink.com/content/35108561nx177313/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00430-011-0216-z
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