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dc.contributor.author Toneatto, Judith
dc.contributor.author Lorenzatti, Guadalupe
dc.contributor.author Cabanillas, Ana Maria de Los A.
dc.contributor.author Arguello, Gerardo
dc.date.available 2018-08-09T17:21:06Z
dc.date.issued 2012-01
dc.identifier.citation Toneatto, Judith; Lorenzatti, Guadalupe; Cabanillas, Ana Maria de Los A.; Arguello, Gerardo; Novel DNA photocleavage properties of [Cr(NN)3]3+ complexes; Elsevier Science; Inorganic Chemistry Communications; 15; 1-2012; 43-46
dc.identifier.issn 1387-7003
dc.identifier.uri http://hdl.handle.net/11336/54797
dc.description.abstract The aim of this study was to investigate the ability of chromium(III) tris-diimine complexes, [Cr(NN)3]3+, to induce DNA photodamage and to examine its capability to impair the survival of irradiated bacteria with the purpose of using these compounds as photocleavage reagents. [Cr(NN)3]3+ complexes, where NN stands for the ligands: phen (1,10-phenanthroline), 5-Mephen, 4,7-diMephen, 3,4,7,8-tetraMephen, 5-Phphen and 5-Clphen were used for this purpose. Their properties of DNA photocleavage were investigated by electrophoretic studies and assays of the photosensitization of transformed bacteria. The results clearly indicate that [Cr(NN)3]3+ complexes promote the photocleavage of plasmid DNA with varied degrees of efficiency after 12 h of irradiation. The combination of DNA, [Cr(NN)3]3+ and light proved to be required to induce the breakdown of DNA. Irradiated plasmid DNA-[Cr(NN) 3]3+ association is also capable of impairing the transforming capacity of bacteria. These results provide evidence which confirms the responsibility and essential role of the excited state of [Cr(NN) 3]3+ for inducing damage. Moreover, assays of the photo sensitization of transformed bacterial suspensions suggest that Escherichia coli may be photo inactivated by irradiation in the presence of [Cr(NN) 3]3+ complexes.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier Science
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject BACTERIAL GROWTH PHOTOINHIBITION
dc.subject BACTERIAL TRANSFORMATION
dc.subject CHROMIUM(III) COMPLEXES
dc.subject DNA PHOTOCLEAVAGE
dc.subject PHOTOSENSITIZATION
dc.subject.classification Otras Ciencias Químicas
dc.subject.classification Ciencias Químicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Novel DNA photocleavage properties of [Cr(NN)3]3+ complexes
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-08-08T18:15:59Z
dc.journal.volume 15
dc.journal.pagination 43-46
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Toneatto, Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.description.fil Fil: Lorenzatti, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil Fil: Cabanillas, Ana Maria de Los A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil Fil: Arguello, Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.journal.title Inorganic Chemistry Communications
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1387700311004771
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.inoche.2011.09.035
dc.conicet.fuente unificacion


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)