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dc.contributor.author
Capdevila, Daiana Andrea
dc.contributor.author
Marmisollé, Waldemar Alejandro
dc.contributor.author
Tomasina, Florencia
dc.contributor.author
Demicheli, Verónica
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Portela, Magdalena
dc.contributor.author
Radi, Rafael
dc.contributor.author
Murgida, Daniel Horacio
dc.date.available
2016-05-03T17:13:54Z
dc.date.issued
2014-09-01
dc.identifier.citation
Capdevila, Daiana Andrea; Marmisollé, Waldemar Alejandro; Tomasina, Florencia; Demicheli, Verónica; Portela, Magdalena ; et al.; Specific methionine oxidation of cytochrome c in complexes with zwitterionic lipids by hydrogen peroxide: potential implications for apoptosis; Royal Society of Chemistry; Chemical Science; 6; 1; 1-9-2014; 705-713
dc.identifier.issn
2041-6520
dc.identifier.uri
http://hdl.handle.net/11336/5476
dc.description.abstract
Cytochrome c (Cyt-c) has been previously shown to participate in cardiolipin (CL) oxidation and, therefore,in mitochondrial membrane permeabilization during the early events of apoptosis. The gain in this function has been ascribed to specific CL/Cyt-c interactions. Here we report that the cationic protein Cyt-c is also able to interact electrostatically with the main lipid components of the mitochondrial membranes, the zwitterionic lipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE), through the mediation of phosphate anions that bind specifically to amino groups in the surfaces of protein and model membranes. In these complexes, Cyt-c reacts efficiently with H2O2 at submillimolar levels, which oxidizes the sulfur atom of the axial ligand Met80. The modified protein is stable and presents significantly enhanced peroxidatic activity. Based on these results, we postulate that the rise of H2O2 concentrations to the submillimolar levels registered during initiation of the apoptotic program may represent one signaling event that triggers the gain in peroxidatic function of the Cyt-c molecules bound to the abundant PE and PC membrane components. As the activated protein is a chemically stable species, it can potentially bind and oxidize important targets, such as CL.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Cytochrome C
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Apoptosis
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Hydrogen Peroxide
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
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Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Specific methionine oxidation of cytochrome c in complexes with zwitterionic lipids by hydrogen peroxide: potential implications for apoptosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-05-06 15:52:43.262787-03
dc.journal.volume
6
dc.journal.number
1
dc.journal.pagination
705-713
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Capdevila, Daiana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de Los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires. Departamento de Ciencias Exactas; Argentina
dc.description.fil
Fil: Marmisollé, Waldemar Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de Los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires. Departamento de Ciencias Exactas; Argentina
dc.description.fil
Fil: Tomasina, Florencia. Universidad de la Republica. Facultad de Medicina; Uruguay
dc.description.fil
Fil: Demicheli, Verónica. Universidad de la Republica. Facultad de Química y Facultad de Ciencias; Uruguay
dc.description.fil
Fil: Portela, Magdalena . Instituto Pasteur de Montevideo; Uruguay
dc.description.fil
Fil: Radi, Rafael . Universidad de la Republica. Facultad de Química y Facultad de Ciencias; Uruguay
dc.description.fil
Fil: Murgida, Daniel Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de Los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires; Argentina
dc.journal.title
Chemical Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2015/SC/c4sc02181a
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1039/c4sc02181a
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/c4sc02181a
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