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Artículo

Increased lymphocyte viability after non-stimulated peripheral blood mononuclear cell (PBMC) culture in patients with X-linked lymphoproliferative disease (XLP)

Belmonte de Zalar, Liliana ElizabethIcon ; Parodi Ramoneda, Cecilia MaríaIcon ; Bastón, Mariela Constanza; Coraglia, Ana CarinaIcon ; Felippo, Marta ElenaIcon ; Baré, PatriciaIcon ; Malbrán, AlejandroIcon ; Ruibal- res, Beatriz; González Bracco, María de las MercedesIcon
Fecha de publicación: 10/2009
Editorial: Academic Press Inc Elsevier Science
Revista: Clinical Immunology
ISSN: 1521-6616
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Médicas

Resumen

Survival of lymphocytes after prolonged culture was studied in two asymptomatic XLP patients. Viability of XLP PBMC after 30 days of non-stimulated culture was higher than that of normal controls (N), mainly due to the persistence of CD8 memory lymphocytes. IFNγ high CD8 T lymphocytes remained higher in XLP than in N after 30 days. The number of perforin+ CD8 lymphocytes was markedly reduced after 30 days in XLP and in N. Increased viability was not related to CD127, PD-1, CD27, or CD62L expression. Concerning B lymphocytes, memory CD27+ CD19+ cells prevailed over CD27- cells after 30 days in both XLP and N, with far more surviving cells in XLP. In N, few CD19+ B lymphocytes were viable after prolonged culture. In XLP, these cells were also IgD+, IgM+ and EBNA2+. These results demonstrate that IFNγ-positive memory CD8 T cells persist in XLP after prolonged culture in association with a subset of viable memory CD27+ B cells expressing latent EBV antigens. The survival advantage of XLP cells might be related to increased frequency of extranodal lymphoma in XLP patients. © 2009 Elsevier Inc. All rights reserved.
Palabras clave: Cd8 Memory Cells , Lymphocyte Viability , Memory B Lymphocytes , Non-Stimulated Culture , Xlp
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/54769
DOI: https://dx.doi.org/10.1016/j.clim.2009.05.015
URL: https://www.sciencedirect.com/science/article/pii/S1521661609006937
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Belmonte de Zalar, Liliana Elizabeth; Parodi Ramoneda, Cecilia María; Bastón, Mariela Constanza; Coraglia, Ana Carina; Felippo, Marta Elena; et al.; Increased lymphocyte viability after non-stimulated peripheral blood mononuclear cell (PBMC) culture in patients with X-linked lymphoproliferative disease (XLP); Academic Press Inc Elsevier Science; Clinical Immunology; 133; 1; 10-2009; 86-94
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