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dc.contributor.author
Riafrecha, Leonardo Ezequiel  
dc.contributor.author
Bua, Silvia  
dc.contributor.author
Supuran, Claudiu T.  
dc.contributor.author
Colinas, Pedro Alfonso  
dc.date.available
2018-08-08T18:37:53Z  
dc.date.issued
2016-07  
dc.identifier.citation
Riafrecha, Leonardo Ezequiel; Bua, Silvia; Supuran, Claudiu T.; Colinas, Pedro Alfonso; Synthesis and carbonic anhydrase inhibitory effects of new N-glycosylsulfonamides incorporating the phenol moiety; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 26; 16; 7-2016; 3892-3895  
dc.identifier.issn
0960-894X  
dc.identifier.uri
http://hdl.handle.net/11336/54631  
dc.description.abstract
A small series of N-glycosylsulfonamides incorporating the phenol moiety has been prepared by Ferrier sulfonamidoglycosylation of D-glycals. N-Glycosides were tested for the inhibition of four isoforms of carbonic anhydrase. In this study, all compounds showed good inhibitory activity against hCA I and II, with selectivity against the cytosolic hCA II versus the tumor associated isozymes. These results confirm that attaching carbohydrate moieties to CA phenol pharmacophore improves and enhances its inhibitory activity.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Carbonic Anhyrases  
dc.subject
Glycomimetic  
dc.subject
Sulfonamidoglycosylation  
dc.subject.classification
Otras Ciencias Químicas  
dc.subject.classification
Ciencias Químicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Synthesis and carbonic anhydrase inhibitory effects of new N-glycosylsulfonamides incorporating the phenol moiety  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-08-08T15:02:01Z  
dc.journal.volume
26  
dc.journal.number
16  
dc.journal.pagination
3892-3895  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Nueva York  
dc.description.fil
Fil: Riafrecha, Leonardo Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Laboratorio de Estudio de Compuestos Orgánicos; Argentina  
dc.description.fil
Fil: Bua, Silvia. Università degli Studi di Firenze; Italia  
dc.description.fil
Fil: Supuran, Claudiu T.. Università degli Studi di Firenze; Italia  
dc.description.fil
Fil: Colinas, Pedro Alfonso. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Laboratorio de Estudio de Compuestos Orgánicos; Argentina  
dc.journal.title
Biorganic and Medicinal Chemistry Letters  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.bmcl.2016.07.015  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960894X1630717X  

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