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dc.contributor.author
Gonzalez, Paula Natalia
dc.contributor.author
Pavlicev, Mihaela
dc.contributor.author
Mitteroecker, Philipp
dc.contributor.author
Pardo Manuel de Villena, Fernando
dc.contributor.author
Spritz, Richard
dc.contributor.author
Marcucio, Ralph
dc.contributor.author
Hallgrimsson, Benedikt
dc.date.available
2018-08-08T16:20:18Z
dc.date.issued
2016-09
dc.identifier.citation
Gonzalez, Paula Natalia; Pavlicev, Mihaela; Mitteroecker, Philipp; Pardo Manuel de Villena, Fernando; Spritz, Richard; et al.; Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel; Blackwell Publishing; Journal of Evolutionary Biology; 29; 9; 9-2016; 1737-1751
dc.identifier.issn
1010-061X
dc.identifier.uri
http://hdl.handle.net/11336/54584
dc.description.abstract
Developmental stability and canalization describe the ability of developmental systems to minimize phenotypic variation in the face of stochastic micro-environmental effects, genetic variation and environmental influences. Canalization is the ability to minimize the effects of genetic or environmental effects, whereas developmental stability is the ability to minimize the effects of micro-environmental effects within individuals. Despite much attention, the mechanisms that underlie these two components of phenotypic robustness remain unknown. We investigated the genetic structure of phenotypic robustness in the collaborative cross (CC) mouse reference population. We analysed the magnitude of fluctuating asymmetry (FA) and among-individual variation of cranial shape in reciprocal crosses among the eight parental strains, using geometric morphometrics and a diallel analysis based on a Bayesian approach. Significant differences among genotypes were found for both measures, although they were poorly correlated at the level of individuals. An overall positive effect of inbreeding was found for both components of variation. The strain CAST/EiJ exerted a positive additive effect on FA and, to a lesser extent, among-individual variance. Sex- and other strain-specific effects were not significant. Neither FA nor among-individual variation was associated with phenotypic extremeness. Our results support the existence of genetic variation for both developmental stability and canalization. This finding is important because robustness is a key feature of developmental systems. Our finding that robustness is not related to phenotypic extremeness is consistent with theoretical work that suggests that its relationship to stabilizing selection is not straightforward.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Blackwell Publishing
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Canalization
dc.subject
Developmental Stability
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Geometric Morphometrics
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Heterozygosity
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Skull
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-08T15:00:32Z
dc.journal.volume
29
dc.journal.number
9
dc.journal.pagination
1737-1751
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Gonzalez, Paula Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - La Plata. Instituto de Genética Veterinaria Ing. Fernando Noel Dulout; Argentina
dc.description.fil
Fil: Pavlicev, Mihaela. Cincinnati Children's Hospital Medical Center
; Estados Unidos
dc.description.fil
Fil: Mitteroecker, Philipp. Universidad de Viena; Austria
dc.description.fil
Fil: Pardo Manuel de Villena, Fernando. No especifica;
dc.description.fil
Fil: Spritz, Richard. University of Colorado; Estados Unidos
dc.description.fil
Fil: Marcucio, Ralph. University of California; Estados Unidos
dc.description.fil
Fil: Hallgrimsson, Benedikt. University of Calgary; Canadá
dc.journal.title
Journal of Evolutionary Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jeb.12906
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jeb.12906
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021570/
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