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dc.contributor.author
Álvarez Colom, Olga
dc.contributor.author
Neske, Adriana Neske
dc.contributor.author
Chahboune, Nadia
dc.contributor.author
Zafra Polo, M. Carmen
dc.contributor.author
Bardon, Alicia del Valle
dc.date.available
2018-08-07T20:23:51Z
dc.date.issued
2009-12
dc.identifier.citation
Álvarez Colom, Olga; Neske, Adriana Neske; Chahboune, Nadia; Zafra Polo, M. Carmen; Bardon, Alicia del Valle; Tucupentol, a novel mono-tetrahydrofuranic acetogenin from Annona montana, as a potent inhibitor of mitochondrial complex I; Wiley VCH Verlag; Chemistry and Biodiversity; 6; 3; 12-2009; 335-340
dc.identifier.issn
1612-1872
dc.identifier.uri
http://hdl.handle.net/11336/54512
dc.description.abstract
Ten acetogenins, one of them new, were isolated from leaves and twigs of a Bolivian collection of Annona montana. The new compound that we named tucupentol (1) is a mono-tetrahydrofuranpentahydroxy-acetogenin. The inhibitory potency of tucupentol (1) on the mitochondrial complex I was evaluated, and this activity was compared with that of the known acetogenins, annonacin-A, cisannonacin-10-one, aromin, and gigantetronenin, also isolated from this plant material. The mentioned acetogenins acted as selective inhibitors of mitochondrial complex I in the 0.8-5.4-nM range.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley VCH Verlag
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Tucupentol, a novel mono-tetrahydrofuranic acetogenin from Annona montana, as a potent inhibitor of mitochondrial complex I
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-06T14:10:23Z
dc.journal.volume
6
dc.journal.number
3
dc.journal.pagination
335-340
dc.journal.pais
Alemania
dc.journal.ciudad
Weinheim
dc.description.fil
Fil: Álvarez Colom, Olga. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; Argentina
dc.description.fil
Fil: Neske, Adriana Neske. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; Argentina
dc.description.fil
Fil: Chahboune, Nadia. Universidad de Valencia; España
dc.description.fil
Fil: Zafra Polo, M. Carmen. Universidad de Valencia; España
dc.description.fil
Fil: Bardon, Alicia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
dc.journal.title
Chemistry and Biodiversity
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1002/cbdv.200800102
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.200800102
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