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dc.contributor.author
Álvarez Colom, Olga  
dc.contributor.author
Neske, Adriana Neske  
dc.contributor.author
Chahboune, Nadia  
dc.contributor.author
Zafra Polo, M. Carmen  
dc.contributor.author
Bardon, Alicia del Valle  
dc.date.available
2018-08-07T20:23:51Z  
dc.date.issued
2009-12  
dc.identifier.citation
Álvarez Colom, Olga; Neske, Adriana Neske; Chahboune, Nadia; Zafra Polo, M. Carmen; Bardon, Alicia del Valle; Tucupentol, a novel mono-tetrahydrofuranic acetogenin from Annona montana, as a potent inhibitor of mitochondrial complex I; Wiley VCH Verlag; Chemistry and Biodiversity; 6; 3; 12-2009; 335-340  
dc.identifier.issn
1612-1872  
dc.identifier.uri
http://hdl.handle.net/11336/54512  
dc.description.abstract
Ten acetogenins, one of them new, were isolated from leaves and twigs of a Bolivian collection of Annona montana. The new compound that we named tucupentol (1) is a mono-tetrahydrofuranpentahydroxy-acetogenin. The inhibitory potency of tucupentol (1) on the mitochondrial complex I was evaluated, and this activity was compared with that of the known acetogenins, annonacin-A, cisannonacin-10-one, aromin, and gigantetronenin, also isolated from this plant material. The mentioned acetogenins acted as selective inhibitors of mitochondrial complex I in the 0.8-5.4-nM range.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley VCH Verlag  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject.classification
Otras Ciencias Químicas  
dc.subject.classification
Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Tucupentol, a novel mono-tetrahydrofuranic acetogenin from Annona montana, as a potent inhibitor of mitochondrial complex I  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-08-06T14:10:23Z  
dc.journal.volume
6  
dc.journal.number
3  
dc.journal.pagination
335-340  
dc.journal.pais
Alemania  
dc.journal.ciudad
Weinheim  
dc.description.fil
Fil: Álvarez Colom, Olga. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; Argentina  
dc.description.fil
Fil: Neske, Adriana Neske. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; Argentina  
dc.description.fil
Fil: Chahboune, Nadia. Universidad de Valencia; España  
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Fil: Zafra Polo, M. Carmen. Universidad de Valencia; España  
dc.description.fil
Fil: Bardon, Alicia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina  
dc.journal.title
Chemistry and Biodiversity  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1002/cbdv.200800102  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.200800102  

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