Artículo
NK cells from tuberculous pleurisy express high ICAM-1 levels and exert stimulatory effect on local T cells
Schierloh, Luis Pablo
; Yokobori, Noemí
; Geffner, Laura Judith
; Balboa, Luciana
; Romero, María Mercedes
; Musella, Rosa María; Alemán, Mercedes
; Castagnino, Jorge; Basile, Juan Ignacio
; de la Barrera, Silvia Susana
; Abbate, Pablo Eduardo; Sasiain, María del Carmen
Fecha de publicación:
09/2009
Editorial:
Wiley VCH Verlag
Revista:
European Journal of Immunology
ISSN:
0014-2980
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Tuberculous pleurisy, one of the most common manifestations of extrapulmonary tuberculosis, is characterized by a T-cell-mediated hypersensitivity reaction along with a Th1 immune profile. In this study, we investigated functional cross-talk among T and NK cells in human tuberculous pleurisy. We found that endogenously activated pleural fluid-derived NK cells express high ICAM-1 levels and induce T-cell activation ex vivo through ICAM-1. Besides, upon in vitro stimulation with monokines and PAMP, resting peripheral blood NK cells increased ICAM-1 expression leading to cellular activation and Th1 polarization of autologous T cells. Furthermore, these effects were abolished by anti-ICAM-1 Ab. Hence, NK cells may contribute to the adaptive immune response by a direct cell-contact-dependent mechanism in the context of Mycobacterium tuberculosis infection. © 2009 Wiley-VCH Verlag GmbH © Co. KGaA.
Palabras clave:
Icam-1
,
Nk Cells
,
Pleurisy
,
Th1
,
Tuberculosis
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Schierloh, Luis Pablo; Yokobori, Noemí; Geffner, Laura Judith; Balboa, Luciana; Romero, María Mercedes; et al.; NK cells from tuberculous pleurisy express high ICAM-1 levels and exert stimulatory effect on local T cells; Wiley VCH Verlag; European Journal of Immunology; 39; 9; 9-2009; 2450-2458
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