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dc.contributor.author
Leal, P. C.
dc.contributor.author
Mascarello, A.
dc.contributor.author
Derita, Marcos Gabriel
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Zuljan, Federico Alberto
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Nunes, R. J.
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Zacchino, Susana Alicia Stella
dc.contributor.author
Yunes, R. A.
dc.date.available
2018-08-07T19:01:00Z
dc.date.issued
2009-03
dc.identifier.citation
Leal, P. C.; Mascarello, A.; Derita, Marcos Gabriel; Zuljan, Federico Alberto; Nunes, R. J.; et al.; Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 19; 6; 3-2009; 1793-1796
dc.identifier.issn
0960-894X
dc.identifier.uri
http://hdl.handle.net/11336/54465
dc.description.abstract
The antifungal activity of a complete series of 15 n-alkyl gallates and six analogues acting against a representative panel of opportunistic pathogenic fungi was studied in order to analyze their role in: the importance of the fungi tested, the importance of the hydroxyls, the influence of the chain length and the hydrophobicity of the compounds. It was demonstrated that dermatophytes were the most susceptible species and that hydroxyls appear to be necessary but not sufficient for the activity. When the log P of each gallate was calculated and related to the different values of MIC against Microsporum gypseum it was observed that hexyl, heptyl, octyl and nonyl gallates exhibit a significant positive deviation from the curve corresponding to a polynomial equation obtained for the other gallates. This suggests that these compounds have a further mode of action besides their hydrophobicity, possibly the inhibition of some enzyme involved in ergosterol biosynthesis. © 2009 Elsevier Ltd. All rights reserved.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antifungal Activity
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Gallates
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Lipophilicity
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-06T14:11:19Z
dc.journal.volume
19
dc.journal.number
6
dc.journal.pagination
1793-1796
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Leal, P. C.. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Mascarello, A.. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Derita, Marcos Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
dc.description.fil
Fil: Zuljan, Federico Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
dc.description.fil
Fil: Nunes, R. J.. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Zacchino, Susana Alicia Stella. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
dc.description.fil
Fil: Yunes, R. A.. Universidade Federal de Santa Catarina; Brasil
dc.journal.title
Biorganic and Medicinal Chemistry Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.bmcl.2009.01.061
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960894X09000845
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