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dc.contributor.author
Lopez, Jorge. L
dc.contributor.author
Garcia Einschlag, Fernando Sebastian
dc.contributor.author
Rives, Carina V.
dc.contributor.author
Villata, Laura S.
dc.contributor.author
Capparelli, Alberto Luis
dc.date.available
2018-08-07T17:13:49Z
dc.date.issued
2004-05
dc.identifier.citation
Lopez, Jorge. L; Garcia Einschlag, Fernando Sebastian; Rives, Carina V.; Villata, Laura S.; Capparelli, Alberto Luis; Physicochemical and toxicological studies on 4-chloro-3,5-dinitrobenzoic acid in aqueous solutions; Society of Environmental Toxicology and Chemistry; Environmental Toxicology and Chemistry; 23; 5; 5-2004; 1129-1135
dc.identifier.issn
0730-7268
dc.identifier.uri
http://hdl.handle.net/11336/54439
dc.description.abstract
Physicochemical characterization of hazardous compounds often is required for the development of structure-reactivity correlations. Physical, chemical, and toxicological properties of target pollutants require determination for an efficient application of wastewater treatments. In the present work, we chose a chloro-nitro-aromatic derivative (4-chloro-3,5-dinitrobenzoic acid [CDNBA]), as a model compound on which to perform physicochemical and toxicological studies. Several properties of CDNBA are not available in the literature, although many aromatic nitro-compounds are considered hazardous materials. Measurements of solubility in water, acid dissociation constant, and kinetic parameters for the nucleophilic substitution of chlorine atom in alkaline media are reported. We also performed cytotoxicity studies of CDNBA and ultraviolet-irradiated CDNBA solutions. From the analysis of CDNBA solubility in water at different temperatures, an enthalpy of solution of 23.2 ± 2.5 kJ/mol was found. The study of the acid dissociation constant Kc by using conductivity measurements and the modified Gran's method yielded values for the equilibrium constant Ka of 2.36 × 10-3 and 2.26 × 10 -3, respectively. The bimolecular rate constant for the reaction of CDNB- and hydroxyl ion (HO-) measured at room temperature and 0.1 M of ionic strength was 5.92/M·s, and the activation energy for this process was 70.7 ± 3.4 kJ/mol. Cytotoxicity assays with aqueous suspensions of Tetrahymena pyriformis showed lethal effects due to the pH change induced by CDNBA. On the other hand, in buffered solutions, a value of 104.47 μM was observed for the median effective concentration, that is, the concentration of CDNBA at which the proliferation was restricted to one half of the blank. Irradiation of CDNBA solutions increased the toxicity, suggesting the formation of intermediate products with higher cytotoxicity effects.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society of Environmental Toxicology and Chemistry
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cytotoxicity
dc.subject
Nitro Compounds
dc.subject
Physicochemical
dc.subject
Properties
dc.subject
Risk Assessment
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Physicochemical and toxicological studies on 4-chloro-3,5-dinitrobenzoic acid in aqueous solutions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-11T14:19:12Z
dc.journal.volume
23
dc.journal.number
5
dc.journal.pagination
1129-1135
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Lopez, Jorge. L. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
dc.description.fil
Fil: Garcia Einschlag, Fernando Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
dc.description.fil
Fil: Rives, Carina V.. Provincia de Buenos Aires. Administración General de Obras Sanitarias; Argentina
dc.description.fil
Fil: Villata, Laura S.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
dc.description.fil
Fil: Capparelli, Alberto Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
dc.journal.title
Environmental Toxicology and Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1897/03-73
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://setac.onlinelibrary.wiley.com/doi/abs/10.1897/03-73


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