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Artículo

Brain circuits mediating the orexigenic action of peripheral ghrelin: Narrow gates for a vast kingdom

Cabral, Agustina SoledadIcon ; de Francesco, Pablo NicolásIcon ; Perello, MarioIcon
Fecha de publicación: 03/2015
Editorial: Frontiers Research Foundation
Revista: Frontiers in Endocrinology
ISSN: 1664-2392
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

The nervous and endocrine systems act together to regulate all physiological processes essential for the body homeostasis control. Given the strict communication restrictions that the brain-blood barrier (BBB) imposes, the interplay between these two systems requires a variety of delicate anatomical interfaces and physiological mechanisms that guarantee the precise function of the neuroendocrine system as a whole. The study of the mechanisms by which hormones act in the brain in order to regulate specific neuronal populations is a research topic rather neglected. Our group studies the neuronal circuitries and molecular mechanisms by which the stomach-produced hormone ghrelin regulates appetite and other physiological functions. A clear notion of the brain targets of peripheral ghrelin is essential for the comprehensive understanding of the physiological role of this hormone. Ghrelin is called "the hunger hormone" since it is the only known orexigenic peptide hormone. The target for ghrelin orexigenic actions is the brain, which contains a variety of ghrelin-responsive nuclei; however, several evidences suggest that the accessibility of peripheral ghrelin to the brain is strikingly low. Here, we briefly summarize the current knowledge in this topic and discuss this intriguing neuroendocrinological issue.
Palabras clave: Appetite , Brain Accessibility , Food Intake
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/54434
DOI: https://dx.doi.org/10.3389/fendo.2015.00044
URL: https://www.frontiersin.org/articles/10.3389/fendo.2015.00044/full
Colecciones
Articulos(IMBICE)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA CELULAR (I)
Citación
Cabral, Agustina Soledad; de Francesco, Pablo Nicolás; Perello, Mario; Brain circuits mediating the orexigenic action of peripheral ghrelin: Narrow gates for a vast kingdom; Frontiers Research Foundation; Frontiers in Endocrinology; 6; MAR; 3-2015; 1-4
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