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dc.contributor.author Calvo Cardona, Samir Julián
dc.contributor.author Cardona Cadavid, Henry
dc.contributor.author Corrales, Juan David
dc.contributor.author Munilla Leguizamon, Sebastian
dc.contributor.author Cantet, Rodolfo Juan Carlos
dc.contributor.author Rogberg Muñoz, Andres
dc.date.available 2018-08-06T19:50:09Z
dc.date.issued 2016-09
dc.identifier.citation Calvo Cardona, Samir Julián; Cardona Cadavid, Henry; Corrales, Juan David; Munilla Leguizamon, Sebastian; Cantet, Rodolfo Juan Carlos; et al.; Longitudinal data analysis of polymorphisms in the κ-casein and β-lactoglobulin genes shows differential effects along the trajectory of the lactation curve in tropical dairy goats; American Dairy Science Association; Journal of Dairy Science; 99; 9; 9-2016; 7299-7307
dc.identifier.issn 0022-0302
dc.identifier.uri http://hdl.handle.net/11336/54325
dc.description.abstract The κ-casein (CSN-3) and β-lactoglobulin (BLG) genes are extensively polymorphic in ruminants. Several association studies have estimated the effects of polymorphisms in these genes on milk yield, milk composition, and cheese-manufacturing properties. Usually, these results are based on production integrated over the lactation curve or on cross-sectional studies at specific days in milk (DIM). However, as differential expression of milk protein genes occurs over lactation, the effect of the polymorphisms may change over time. In this study, we fitted a mixed-effects regression model to test-day records of milk yield and milk quality traits (fat, protein, and total solids yields) from Colombian tropical dairy goats. We used the well-characterized A/B polymorphisms in the CSN-3 and BLG genes. We argued that this approach provided more efficient estimators than cross-sectional designs, given the same number and pattern of observations, and allowed exclusion of between-subject variation from model error. The BLG genotype AA showed a greater performance than the BB genotype for all traits along the whole lactation curve, whereas the heterozygote showed an intermediate performance. We observed no such constant pattern for the CSN-3 gene between the AA homozygote and the heterozygote (the BB genotype was absent from the sample). The differences among the genotypic effects of the BLG and the CSN-3 polymorphisms were statistically significant during peak and mid lactation (around 40–160 DIM) for the BLG gene and only for mid lactation (80–145 DIM) for the CSN-3 gene. We also estimated the additive and dominant effects of the BLG locus. The locus showed a statistically significant additive behavior along the whole lactation trajectory for all quality traits, whereas for milk yield the effect was not significant at later stages. In turn, we detected a statistically significant dominance effect only for fat yield in the early and peak stages of lactation (at about 1–45 DIM). The longitudinal analysis of test-day records allowed us to estimate the differential effects of polymorphisms along the lactation curve, pointing toward stages that could be affected by the gene.
dc.format application/pdf
dc.language.iso eng
dc.publisher American Dairy Science Association
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject ADDITIVE
dc.subject DAIRY GOATS
dc.subject DOMINANCE
dc.subject LONGITUDINAL DATA
dc.subject Β-LACTOGLOBULIN
dc.subject Κ-CASEIN
dc.subject.classification Otras Producción Animal y Lechería
dc.subject.classification Producción Animal y Lechería
dc.subject.classification CIENCIAS AGRÍCOLAS
dc.title Longitudinal data analysis of polymorphisms in the κ-casein and β-lactoglobulin genes shows differential effects along the trajectory of the lactation curve in tropical dairy goats
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-06-22T14:33:07Z
dc.journal.volume 99
dc.journal.number 9
dc.journal.pagination 7299-7307
dc.journal.pais Estados Unidos
dc.journal.ciudad Illinois
dc.description.fil Fil: Calvo Cardona, Samir Julián. Universidad de Antioquia; Colombia
dc.description.fil Fil: Cardona Cadavid, Henry. Universidad de Antioquia; Colombia
dc.description.fil Fil: Corrales, Juan David. Universidad de La Salle; Colombia. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Animal; Argentina
dc.description.fil Fil: Munilla Leguizamon, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Animal; Argentina
dc.description.fil Fil: Cantet, Rodolfo Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; Argentina. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Animal; Argentina
dc.description.fil Fil: Rogberg Muñoz, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - La Plata. Instituto de Genética Veterinaria Ing. Fernando Noel Dulout; Argentina. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Animal; Argentina
dc.journal.title Journal of Dairy Science
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.3168/jds.2016-10954
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022030216304477
dc.conicet.fuente individual


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)