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dc.contributor.author
Calvo Cardona, Samir Julián  
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Cardona Cadavid, Henry  
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Corrales, Juan David  
dc.contributor.author
Munilla Leguizamon, Sebastian  
dc.contributor.author
Cantet, Rodolfo Juan Carlos  
dc.contributor.author
Rogberg Muñoz, Andres  
dc.date.available
2018-08-06T19:50:09Z  
dc.date.issued
2016-09  
dc.identifier.citation
Calvo Cardona, Samir Julián; Cardona Cadavid, Henry; Corrales, Juan David; Munilla Leguizamon, Sebastian; Cantet, Rodolfo Juan Carlos; et al.; Longitudinal data analysis of polymorphisms in the κ-casein and β-lactoglobulin genes shows differential effects along the trajectory of the lactation curve in tropical dairy goats; American Dairy Science Association; Journal of Dairy Science; 99; 9; 9-2016; 7299-7307  
dc.identifier.issn
0022-0302  
dc.identifier.uri
http://hdl.handle.net/11336/54325  
dc.description.abstract
The κ-casein (CSN-3) and β-lactoglobulin (BLG) genes are extensively polymorphic in ruminants. Several association studies have estimated the effects of polymorphisms in these genes on milk yield, milk composition, and cheese-manufacturing properties. Usually, these results are based on production integrated over the lactation curve or on cross-sectional studies at specific days in milk (DIM). However, as differential expression of milk protein genes occurs over lactation, the effect of the polymorphisms may change over time. In this study, we fitted a mixed-effects regression model to test-day records of milk yield and milk quality traits (fat, protein, and total solids yields) from Colombian tropical dairy goats. We used the well-characterized A/B polymorphisms in the CSN-3 and BLG genes. We argued that this approach provided more efficient estimators than cross-sectional designs, given the same number and pattern of observations, and allowed exclusion of between-subject variation from model error. The BLG genotype AA showed a greater performance than the BB genotype for all traits along the whole lactation curve, whereas the heterozygote showed an intermediate performance. We observed no such constant pattern for the CSN-3 gene between the AA homozygote and the heterozygote (the BB genotype was absent from the sample). The differences among the genotypic effects of the BLG and the CSN-3 polymorphisms were statistically significant during peak and mid lactation (around 40–160 DIM) for the BLG gene and only for mid lactation (80–145 DIM) for the CSN-3 gene. We also estimated the additive and dominant effects of the BLG locus. The locus showed a statistically significant additive behavior along the whole lactation trajectory for all quality traits, whereas for milk yield the effect was not significant at later stages. In turn, we detected a statistically significant dominance effect only for fat yield in the early and peak stages of lactation (at about 1–45 DIM). The longitudinal analysis of test-day records allowed us to estimate the differential effects of polymorphisms along the lactation curve, pointing toward stages that could be affected by the gene.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Dairy Science Association  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Additive  
dc.subject
Dairy Goats  
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Dominance  
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Longitudinal Data  
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Β-Lactoglobulin  
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Κ-Casein  
dc.subject.classification
Otras Producción Animal y Lechería  
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Producción Animal y Lechería  
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CIENCIAS AGRÍCOLAS  
dc.title
Longitudinal data analysis of polymorphisms in the κ-casein and β-lactoglobulin genes shows differential effects along the trajectory of the lactation curve in tropical dairy goats  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-06-22T14:33:07Z  
dc.journal.volume
99  
dc.journal.number
9  
dc.journal.pagination
7299-7307  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Illinois  
dc.description.fil
Fil: Calvo Cardona, Samir Julián. Universidad de Antioquia; Colombia  
dc.description.fil
Fil: Cardona Cadavid, Henry. Universidad de Antioquia; Colombia  
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Fil: Corrales, Juan David. Universidad de La Salle; Colombia. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Animal; Argentina  
dc.description.fil
Fil: Munilla Leguizamon, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Animal; Argentina  
dc.description.fil
Fil: Cantet, Rodolfo Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; Argentina. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Animal; Argentina  
dc.description.fil
Fil: Rogberg Muñoz, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - La Plata. Instituto de Genética Veterinaria Ing. Fernando Noel Dulout; Argentina. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Animal; Argentina  
dc.journal.title
Journal of Dairy Science  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.3168/jds.2016-10954  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022030216304477