Artículo
Tailored Multi-Target Agents: Applications and Design Considerations
Fecha de publicación:
03/2016
Editorial:
Bentham Science Publishers
Revista:
Current Pharmaceutical Design
ISSN:
1381-6128
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in fact unintended multi-functional therapeutics that have emerged from phenotypic models. The last two decades, however, have witnessed the emergence of tailored multi-target agents, which according to our perspective combine the best aspects of target-based and phenotypic-based drug discovery. Here we discuss a number of considerations related to the design, screening and computer-aided discovery of multi-targeted drugs, along with neglected advantages that this type of agents might have in clinical trials.
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Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Talevi, Alan; Tailored Multi-Target Agents: Applications and Design Considerations; Bentham Science Publishers; Current Pharmaceutical Design; 22; 21; 3-2016; 3164-3170
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