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dc.contributor.author
Abraham, Gustavo Abel
dc.contributor.author
De Queiroz, Alvaro A.A
dc.contributor.author
Román, Julio San
dc.date.available
2018-08-06T13:08:36Z
dc.date.issued
2002-04
dc.identifier.citation
Abraham, Gustavo Abel; De Queiroz, Alvaro A.A; Román, Julio San; Immobilization of a nonsteroidal antiinflammatory drug onto commercial segmented polyurethane surface to improve haemocompatibility properties; Elsevier; Biomaterials; 23; 7; 4-2002; 1625-1638
dc.identifier.issn
0142-9612
dc.identifier.uri
http://hdl.handle.net/11336/54233
dc.description.abstract
A method has been developed in which a layer of p-aminosalicylic acid (4-amino-2-hydroxybenzoic acid) (PAS), a water soluble pharmaceutical compound of the nonsteroidal anti-inflammatory drug (NSAID) class with antiaggregant platelet activity, is covalently immobilized onto a segmented polyurethane, Biospan™ (SPU) surface. Thus, SPU surfaces were modified by grafting of hexamethylenediisocyanate, and the free isocyanate remaining on the SPU surface were then coupled through a condensation reaction to amine groups of p-aminosalicylic acid. The bonding of PAS from aqueous solution onto SPU surface was studied by ATR-FTIR, UV and fluorescence spectroscopy. Plateau levels of coupled PAS were reached within 1.2μg/cm2 using PAS solution concentrations of 1mg/ml. The surface wettability of the polymeric films measured by contact angle indicate that the introduction of the PAS turns the surface more hydrophilic (θwater=43.1°±2.1°) relatively to the original SPU films (θwater=70.3°±1.9°). The in vitro albumin (BSA) adsorption shows that the PAS-SPU films adsorb more BSA (250/μgmm2) than the original SPU (112μg/mm2). Thrombogenicity was assessed by measuring the thrombus formation and platelet adhesion of the SPU containing PAS relatively to nonmodified SPU surfaces. The polymeric surfaces with immobilized PAS had better nonthrombogenic characteristics as indicated by the low platelet adhesion, high adsorption of albumin relatively to fibrinogen and low thrombus formation, making them potentially good candidates for biomedical applications. © 2002 Elsevier Science Ltd. All rights reserved.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Albumin
dc.subject
Biospan&Trade;
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P-Aminobenzoic Acid
dc.subject
Segmented Polyurethanes
dc.subject
Thrombogenicity
dc.subject.classification
Tecnologías que involucran la manipulación de células, tejidos, órganos o todo el organismo
dc.subject.classification
Biotecnología de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Immobilization of a nonsteroidal antiinflammatory drug onto commercial segmented polyurethane surface to improve haemocompatibility properties
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-11T17:26:56Z
dc.journal.volume
23
dc.journal.number
7
dc.journal.pagination
1625-1638
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.description.fil
Fil: De Queiroz, Alvaro A.A. Escola Federal de Engenharia de Itajubá; Brasil
dc.description.fil
Fil: Román, Julio San. Consejo Superior de Investigaciones Científicas; España
dc.journal.title
Biomaterials
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/S0142-9612(01)00289-7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0142961201002897
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