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dc.contributor.author
Abraham, Gustavo Abel  
dc.contributor.author
De Queiroz, Alvaro A.A  
dc.contributor.author
Román, Julio San  
dc.date.available
2018-08-06T13:08:36Z  
dc.date.issued
2002-04  
dc.identifier.citation
Abraham, Gustavo Abel; De Queiroz, Alvaro A.A; Román, Julio San; Immobilization of a nonsteroidal antiinflammatory drug onto commercial segmented polyurethane surface to improve haemocompatibility properties; Elsevier; Biomaterials; 23; 7; 4-2002; 1625-1638  
dc.identifier.issn
0142-9612  
dc.identifier.uri
http://hdl.handle.net/11336/54233  
dc.description.abstract
A method has been developed in which a layer of p-aminosalicylic acid (4-amino-2-hydroxybenzoic acid) (PAS), a water soluble pharmaceutical compound of the nonsteroidal anti-inflammatory drug (NSAID) class with antiaggregant platelet activity, is covalently immobilized onto a segmented polyurethane, Biospan™ (SPU) surface. Thus, SPU surfaces were modified by grafting of hexamethylenediisocyanate, and the free isocyanate remaining on the SPU surface were then coupled through a condensation reaction to amine groups of p-aminosalicylic acid. The bonding of PAS from aqueous solution onto SPU surface was studied by ATR-FTIR, UV and fluorescence spectroscopy. Plateau levels of coupled PAS were reached within 1.2μg/cm2 using PAS solution concentrations of 1mg/ml. The surface wettability of the polymeric films measured by contact angle indicate that the introduction of the PAS turns the surface more hydrophilic (θwater=43.1°±2.1°) relatively to the original SPU films (θwater=70.3°±1.9°). The in vitro albumin (BSA) adsorption shows that the PAS-SPU films adsorb more BSA (250/μgmm2) than the original SPU (112μg/mm2). Thrombogenicity was assessed by measuring the thrombus formation and platelet adhesion of the SPU containing PAS relatively to nonmodified SPU surfaces. The polymeric surfaces with immobilized PAS had better nonthrombogenic characteristics as indicated by the low platelet adhesion, high adsorption of albumin relatively to fibrinogen and low thrombus formation, making them potentially good candidates for biomedical applications. © 2002 Elsevier Science Ltd. All rights reserved.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Albumin  
dc.subject
Biospan&Trade;  
dc.subject
P-Aminobenzoic Acid  
dc.subject
Segmented Polyurethanes  
dc.subject
Thrombogenicity  
dc.subject.classification
Tecnologías que involucran la manipulación de células, tejidos, órganos o todo el organismo  
dc.subject.classification
Biotecnología de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica  
dc.subject.classification
Ciencias Químicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Immobilization of a nonsteroidal antiinflammatory drug onto commercial segmented polyurethane surface to improve haemocompatibility properties  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-07-11T17:26:56Z  
dc.journal.volume
23  
dc.journal.number
7  
dc.journal.pagination
1625-1638  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina  
dc.description.fil
Fil: De Queiroz, Alvaro A.A. Escola Federal de Engenharia de Itajubá; Brasil  
dc.description.fil
Fil: Román, Julio San. Consejo Superior de Investigaciones Científicas; España  
dc.journal.title
Biomaterials  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/S0142-9612(01)00289-7  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0142961201002897