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dc.contributor.author
Pérez Lloret, Santiago
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dc.contributor.author
Rossi, Malco Damián
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dc.contributor.author
Cardinali, Daniel Pedro
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dc.contributor.author
Merello, Marcelo Jorge
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dc.date.available
2018-07-31T20:00:03Z
dc.date.issued
2010-02
dc.identifier.citation
Pérez Lloret, Santiago; Rossi, Malco Damián; Cardinali, Daniel Pedro; Merello, Marcelo Jorge; Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease; Taylor & Francis Ltd; The International Journal Of Neuroscience.; 120; 2; 2-2010; 137-143
dc.identifier.issn
0020-7454
dc.identifier.uri
http://hdl.handle.net/11336/53664
dc.description.abstract
Background: There is growing interest in developing inexpensive and objective motor fluctuation evaluation methods for Parkinson's disease (PD). Objectives: We aim to compare activity level in the off state, on state, and dyskinetic periods as evaluated either by a physician during a levodopa challenge or by a 72-hr onoff diary self-evaluation in the ambulatory setting. Finally, the effect of daily activities on motor activity in PD and healthy controls was further explored. Methods: The study was conducted in three consecutive phases. For phase I, in which the on state, off state, and dyskinesia were evaluated using actigraphy, recordings were made during standard acute levodopa challenge in nine dyskinetic PD patients. For phase II, a different set of 16 dyskinetic PD patients was monitored in the ambulatory setting for 72 consecutive hours by actigraphy and a standardized onoff diary. For phase III, 62 PD patients and 14 age- and sex-matched healthy controls wore an actigraph and completed a daily activities diary for 7 days. Results: No differences in activity level between on state and off state during the acute levodopa challenge (phase I) or the 72-hr ambulatory period (phase II) were found. Activity during dyskinesia periods was significantly higher than during on state periods without dyskinesia (p < .01). During the third phase, dyskinetic PD patients and healthy controls showed higher actigraphy-measured activity as compared to de novo, stable, or fluctuating PD (p < .0001), which remained unaltered by daily activities performed during the study period. Tremor UPDRS scores did not correlate with activity level. Conclusions: These results confirm the lack of specificity of simple wrist-worn actigraphy and further suggest it may be suitable for dyskinesia assessment but not for on state and off state evaluation. Copyright © 2010 Informa Healthcare USA, Inc.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis Ltd
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Actigraphy
dc.subject
Dyskinesia
dc.subject
Motor Fluctuations
dc.subject
Parkinson'S Disease
dc.subject.classification
Medicina Critica y de Emergencia
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-30T15:42:16Z
dc.journal.volume
120
dc.journal.number
2
dc.journal.pagination
137-143
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Rossi, Malco Damián. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Merello, Marcelo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina
dc.journal.title
The International Journal Of Neuroscience.
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.3109/00207450903139663
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/00207450903139663?journalCode=ines20
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