Artículo
Decision-making in Parkinson's disease patients with and without pathological gambling
Rossi, Malco Damián; Roldán Gerschcovich, Eliana; de Achaval, Delfina
; Pérez Lloret, Santiago
; Cerquetti, Daniel; Cammarota, Adrian Aldo
; Nouzeilles, M. Ines; Fahrer, Rodolfo D.; Merello, Marcelo Jorge
; Leiguarda, Ramón Carlos
Fecha de publicación:
01/2010
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
European Journal of Neurology
ISSN:
1351-5101
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background and purpose: Pathological gambling (PG) in Parkinson's disease (PD) is a frequent impulse control disorder associated mainly with dopamine replacement therapy. As impairments in decision-making were described independently in PG and PD, the objective of this study was to assess decision-making processes in PD patients with and without PG. Methods: Seven PD patients with PG and 13 age, sex, education and disease severity matched PD patients without gambling behavior were enrolled in the study. All patients were assessed with a comprehensive neuropsychiatric and cognitive evaluation, including tasks used to assess decision-making abilities under ambiguous or risky situations, like the Iowa Gambling Task (IGT), the Game of Dice Task and the Investment Task. Results: Compared to PD patients without gambling behavior, those with PG obtained poorer scores in the IGT and in a rating scale of social behavior, but not in other decision-making and cognitive tasks. Conclusions: Low performance in decision-making under ambiguity and abnormal social behavior distinguished PD patients with PG from those without this disorder. Dopamine replacement therapy may induce dysfunction of the ventromedial prefrontal cortex and amygdala-ventral striatum system, thus increasing the risk for developing PG. © 2009 EFNS.
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Articulos(SEDE CENTRAL)
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Articulos de SEDE CENTRAL
Citación
Rossi, Malco Damián; Roldán Gerschcovich, Eliana; de Achaval, Delfina; Pérez Lloret, Santiago; Cerquetti, Daniel; et al.; Decision-making in Parkinson's disease patients with and without pathological gambling; Wiley Blackwell Publishing, Inc; European Journal of Neurology; 17; 1; 1-2010; 97-102
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