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dc.contributor.author
Metz, German Ernesto

dc.contributor.author
Galindo, Inmaculada
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Abeyá, María Mercedes

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Echeverria, Maria Gabriela

dc.contributor.author
Alonso, Covadonga
dc.date.available
2018-07-31T18:58:24Z
dc.date.issued
2016-02
dc.identifier.citation
Metz, German Ernesto; Galindo, Inmaculada; Abeyá, María Mercedes; Echeverria, Maria Gabriela; Alonso, Covadonga; Intrinsic, extrinsic and endoplasmic reticulum stress-induced apoptosis in RK13 cells infected with equine arteritis virus; Elsevier Science; Virus Research; 213; 2-2016; 219-223
dc.identifier.issn
0168-1702
dc.identifier.uri
http://hdl.handle.net/11336/53631
dc.description.abstract
The modulation of the expression of caspases by viruses influences the cell survival of different cell types. Equine arteritis virus (EAV) induces apoptosis of BHK21 and Vero cell lines, but it is not known whether EAV induces apoptosis in RK13 cells, a common cell line routinely used in EAV diagnosis and research. In this study, we determined that caspase-3 expression was triggered after infection of RK13 cells with EAV in a time- and dose-dependent manner. We also detected caspase-8 and caspase-9 activation, indicating the stimulation of both extrinsic and intrinsic apoptosis pathways. Finally, we found caspase-12 activation, an indicator of endoplasmic reticulum stress-induced apoptosis. The variability observed in the apoptotic response in the different cell lines demonstrates that apoptosis depends on the distinctive sensitivity of each cell line used for investigation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science

dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Apoptosis
dc.subject
Arterivirus
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Caspases
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Equine Arteritis Virus
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Er Stress
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Otras Ciencias Biológicas

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Ciencias Biológicas

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CIENCIAS NATURALES Y EXACTAS

dc.title
Intrinsic, extrinsic and endoplasmic reticulum stress-induced apoptosis in RK13 cells infected with equine arteritis virus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-31T17:18:47Z
dc.journal.volume
213
dc.journal.pagination
219-223
dc.journal.pais
Países Bajos

dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Metz, German Ernesto. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Galindo, Inmaculada. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria; España
dc.description.fil
Fil: Abeyá, María Mercedes. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Echeverria, Maria Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Alonso, Covadonga. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria; España
dc.journal.title
Virus Research

dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0168170215301684
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.virusres.2015.12.010
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