Mostrar el registro sencillo del ítem
dc.contributor.author
López Soto, Eduardo Javier
dc.contributor.author
Catanesi, Cecilia Ines
dc.date.available
2018-07-30T20:35:18Z
dc.date.issued
2015-06
dc.identifier.citation
López Soto, Eduardo Javier; Catanesi, Cecilia Ines; Human population genetic structure detected by pain-related mu opioid receptor gene polymorphisms; Sociedade Brasileira de Genética; Genetics and Molecular Biology; 38; 2; 6-2015; 152-155
dc.identifier.issn
1415-4757
dc.identifier.uri
http://hdl.handle.net/11336/53492
dc.description.abstract
Several single nucleotide polymorphisms (SNPs) in the Mu Opioid Receptor gene (OPRM1) have been identified and associated with a wide variety of clinical phenotypes related both to pain sensitivity and analgesic requirements. The A118G and other potentially functional OPRM1 SNPs show significant differences in their allele distributions among populations. However, they have not been properly addressed in a population genetic analysis. Population stratification could lead to erroneous conclusions when they are not taken into account in association studies. The aim of our study was to analyze OPRM1 SNP variability by comparing population samples of the International Hap Map database and to analyze a new population sample from the city of Corrientes, Argentina. The results confirm that OPRM1 SNP variability differs among human populations and displays a clear ancestry genetic structure, with three population clusters: Africa, Asia, and Europe-America.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Sociedade Brasileira de Genética
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
A118g
dc.subject
Amova
dc.subject
Oprm1
dc.subject
Population Genetics
dc.subject
Snps
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Human population genetic structure detected by pain-related mu opioid receptor gene polymorphisms
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-30T13:36:49Z
dc.identifier.eissn
1678-4685
dc.journal.volume
38
dc.journal.number
2
dc.journal.pagination
152-155
dc.journal.pais
Brasil
dc.journal.ciudad
Ribeirão Preto
dc.description.fil
Fil: López Soto, Eduardo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
dc.description.fil
Fil: Catanesi, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; Argentina
dc.journal.title
Genetics and Molecular Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530646/pdf/1415-4757-gmb-38-2-152.pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1590/S1415-4757382220140299
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/95cwcy
Archivos asociados