Artículo
Modeling and estimation of production rate for the production phase of non-growth-associated high cell density processes
Jamilis Ricaldoni, Martín Ignacio
; Garelli, Fabricio
; Mozumder, Md Salatul Islam; Castañeda, María Teresita
; de Battista, Hernán
Fecha de publicación:
10/2015
Editorial:
Springer
Revista:
Bioprocess and biosystems engineering
ISSN:
1615-7605
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This paper addresses the estimation of the specific production rate of intracellular products and the modeling of the bioreactor volume dynamics in high cell density fed-batch reactors. In particular, a new model for the bioreactor volume is proposed, suitable to be used in high cell density cultures where large amounts of intracellular products are stored. Based on the proposed volume model, two forms of a high-order sliding mode observer are proposed. Each form corresponds to the cases with residual biomass concentration or volume measurement, respectively. The observers achieve finite time convergence and robustness to process uncertainties as the kinetic model is not required. Stability proofs for the proposed observer are given. The observer algorithm is assessed numerically and experimentally.
Palabras clave:
Estimation
,
High Cell Density
,
Observer
,
Sliding Mode
,
Volume Model
Archivos asociados
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Identificadores
Colecciones
Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos(CINDEFI)
Articulos de CENT.DE INV EN FERMENTACIONES INDUSTRIALES (I)
Articulos de CENT.DE INV EN FERMENTACIONES INDUSTRIALES (I)
Citación
Jamilis Ricaldoni, Martín Ignacio; Garelli, Fabricio; Mozumder, Md Salatul Islam; Castañeda, María Teresita; de Battista, Hernán; Modeling and estimation of production rate for the production phase of non-growth-associated high cell density processes; Springer; Bioprocess and biosystems engineering; 38; 10; 10-2015; 1903-1914
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