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dc.contributor.author Menezes Cordeiro, Inês
dc.contributor.author Von Ellenrieder, Nicolás
dc.contributor.author Zazubovits, Natalja
dc.contributor.author Dubeau, François
dc.contributor.author Gotman, Jean
dc.contributor.author Frauscher, Birgit
dc.date.available 2018-07-30T16:24:55Z
dc.date.issued 2015-07
dc.identifier.citation Menezes Cordeiro, Inês; Von Ellenrieder, Nicolás; Zazubovits, Natalja; Dubeau, François; Gotman, Jean; et al.; Sleep influences the intracerebral EEG pattern of focal cortical dysplasia; Elsevier Science; Epilepsy Research; 113; 7-2015; 132-139
dc.identifier.issn 0920-1211
dc.identifier.uri http://hdl.handle.net/11336/53399
dc.description.abstract We analyze the distribution of intracerebral EEG patterns of FCD in relation to sleep. FCD interictal EEG patterns are present between 45% and 97% of the time analyzed. Despite almost continuous spiking, sleep is an important modulator of FCD EEG patterns. This suggests that dysplastic tissue is under thalamocortical control. Objective: Focal cortical dysplasia (FCD) is able to generate an intrinsic pathological EEG activity characterized by a continuous or near-continuous spiking. Different patterns of discharge were described. We examined quantitatively the distribution of the intracerebral FCD patterns in relation to sleep in order to investigate whether this activity is independent of thalamocortical influences. Methods: We analyzed the first sleep cycle of 5 patients with a diagnosis of FCD type II who underwent combined scalp-intracranial electroencephalography (EEG), and showed an intracranial EEG pattern typical for FCD. Three patterns of FCD intracranial EEG activity were identified in all 5 patients, and visually marked for a maximum of 30. min of each stage (wake, N1, N2, N3, REM): spike or polyspike exceeding 2. Hz (pattern 1), spike or polyspike interrupted by flat periods below 2. Hz (pattern 2) and discharges of >15. Hz low-voltage rhythmic activity with regular morphology (pattern 3). After marking, the percentages of the three patterns across the different stages were calculated. Results: The three patterns of FCD were present between 45% and 97% of the total time analyzed. Pattern 1 was the predominant pattern in wakefulness (73-100%), N1 (76-97%) and N2 (58-88.5%) in all patients, and in REM in 4 of 5 patients (91-100%). During N2 and N3, there was an increase in pattern 2 in all patients, becoming the predominant pattern in 3 of the 5 patients during N3 (63-89%). Pattern 3 was rare and only sporadically observed during N2 and N3. Wakefulness and REM sleep showed a similar pattern (pattern 1) with a slight amplitude reduction in REM sleep. Significance: Despite the presence of an almost continuous discharge, sleep is an important modulator of the pathological EEG patterns found in FCD type II. This might suggest that dysplastic tissue is influenced by the thalamo-cortical control mechanisms involved in the generation of sleep.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier Science
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject AASM
dc.subject EPILEPSY
dc.subject INTERICTAL
dc.subject INTRACEREBRAL EEG
dc.subject POLYSOMNOGRAPHY
dc.subject THALAMO-CORTICAL
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Sleep influences the intracerebral EEG pattern of focal cortical dysplasia
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-07-30T13:34:47Z
dc.journal.volume 113
dc.journal.pagination 132-139
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Menezes Cordeiro, Inês. McGill University; Canadá. Faro Hospital; Portugal
dc.description.fil Fil: Von Ellenrieder, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. McGill University; Canadá
dc.description.fil Fil: Zazubovits, Natalja. McGill University; Canadá
dc.description.fil Fil: Dubeau, François. McGill University; Canadá
dc.description.fil Fil: Gotman, Jean. McGill University; Canadá
dc.description.fil Fil: Frauscher, Birgit. McGill University; Canadá. Universidad de Innsbruck; Austria
dc.journal.title Epilepsy Research
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.eplepsyres.2015.03.014
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0920121115000698
dc.conicet.fuente individual


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)