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Artículo

Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina

Fabricius, GabrielIcon ; Bergero, Paula ElenaIcon ; Ormazabal, Maximiliano EmanuelIcon ; Maltz, Alberto; Hozbor, Daniela Flavia
Fecha de publicación: 06/2012
Editorial: Cambridge University Press
Revista: Epidemiology and Infection
ISSN: 0950-2688
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Matemática Aplicada; Enfermedades Infecciosas; Biofísica

Resumen

Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0-1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.
Palabras clave: Epidemic , Mathematical Modelling , Pertussis , Tdap Booster
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/5335
URL: http://journals.cambridge.org/abstract_S0950268812001380
DOI: http://dx.doi.org/10.1017/S0950268812001380
DOI: http://dx.doi.org/ 10.1017/S0950268812001380
Colecciones
Articulos(IBBM)
Articulos de INST.DE BIOTECNOLOGIA Y BIOLOGIA MOLECULAR
Articulos(INIFTA)
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Citación
Fabricius, Gabriel; Bergero, Paula Elena; Ormazabal, Maximiliano Emanuel; Maltz, Alberto; Hozbor, Daniela Flavia; Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina; Cambridge University Press; Epidemiology and Infection; 141; 4; 6-2012; 718-734
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