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Artículo

Natural history of human papillomavirus infection of sun-exposed healthy skin of immunocompetent individuals over three climatic seasons and identification of HPV209, a novel betapapillomavirus

Bolatti, Elisa MariaIcon ; Chouhy, DiegoIcon ; Hošnjak, Lea; Casal, Pablo E.; Kocjan, Boštjan J.; Bottai, Hebe; Stella, Emma JulietaIcon ; Sanchez, Adriana; Bussy, Ramón Fernandez; Poljak, Mario; Giri, Adriana AngelicaIcon
Fecha de publicación: 06/2017
Editorial: Society for General Microbiology
Revista: Journal of General Virology
ISSN: 0022-1317
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

We present the first longitudinal study reporting the natural history of human papillomavirus (HPV) infection in sun-exposed skin of healthy individuals living in a geographical area in which solar UV radiation is influenced by the ozone content of the atmosphere. During three climatic seasons, skin swab samples were obtained from 78 healthy individuals and the prevalence of cutaneous HPVs was assessed with broad-spectrum FAP and CUT primers and determined at 54, 45 and 47 % in spring, summer and winter, respectively. Frequencies of mixed HPV infections were significantly higher in spring with respect to summer and winter (P=0.02). Seventy-one different HPV types/putative types were identified. While 62 volunteers were HPV-infected in at least one season, 23 had persistent infections. β-PVs (β-1) were the most prevalent and persistent. Age was associated with both the infection status (P=0.01) and the type of HPV infection (no infection, indeterminate/ transient, persistent P=0.02). The molecular/phylogenetic analysis of the newly identified β-PV, officially designated as HPV209, showed that the virus has a typical genomic organization of cutaneous HPVs with five early (E6, E7, E1, E2 and E4) and two late genes (L2 and L1), which clusters to the species β-2. This provides useful data on cutaneous HPV infections in high UV-exposed regions.
Palabras clave: Climatic Seasons , Hpv209 , Human Papillomavirus Infection , Persistence , Prevalence , Sun-Exposed Healthy Skin
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/53328
DOI: https://dx.doi.org/10.1099/jgv.0.000774
URL: http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000774
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Articulos(IBR) [640]
Articulos de INST.DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Citación
Bolatti, Elisa Maria; Chouhy, Diego; Hošnjak, Lea; Casal, Pablo E.; Kocjan, Boštjan J.; et al.; Natural history of human papillomavirus infection of sun-exposed healthy skin of immunocompetent individuals over three climatic seasons and identification of HPV209, a novel betapapillomavirus; Society for General Microbiology; Journal of General Virology; 98; 6; 6-2017; 1334-1348
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