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Artículo

Benzalkonium chloride breaks down conjunctival immunological tolerance in a murine model

Galletti, Jeremías GastónIcon ; Gabelloni, María LauraIcon ; Morande, Pablo ElíasIcon ; Sabbione, FlorenciaIcon ; Vermeulen, Elba MonicaIcon ; Trevani, Analía SilvinaIcon ; Giordano, Mirta NildaIcon
Fecha de publicación: 06/2012
Editorial: Nature Publishing Group
Revista: Mucosal Immunology
ISSN: 1933-0219
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

The impact of topical eye drops with benzalkonium chloride (BAK) as a preservative could involve more than the reported toxic effects on the ocular surface epithelium and ultimately affect the immune balance of the conjunctiva. We found that BAK not only impairs tolerance induction in a murine model, but leads to mild systemic immunization. Contrasting with antigen only-treated mice, there was no induction of interleukin 10-producing antigen-specific CD4 + cells in BAK-treated animals. Moreover, the tolerogenic capacity of migrating dendritic cells (DCs) was reduced, apparently involving differential conditioning by soluble epithelial factors. Accordingly, epithelial cells exposed in vitro to BAK were less suppressive and failed to induce tolerogenic DCs in culture. As this effect of BAK was dependent on epithelial nuclear factor κB pathway activation, our findings may provide new therapeutic targets. Thus, tolerance breakdown by BAK should be considered an important factor in the management of glaucoma and immune-mediated ocular surface disorders. © 2013 Society for Mucosal Immunology.
Palabras clave: Benzalkonium , Tolerance , Immunology , Conjuntiva
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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URI: http://hdl.handle.net/11336/53314
DOI: https://dx.doi.org/10.1038/mi.2012.44
URL: https://www.nature.com/articles/mi201244
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Galletti, Jeremías Gastón; Gabelloni, María Laura; Morande, Pablo Elías; Sabbione, Florencia; Vermeulen, Elba Monica; et al.; Benzalkonium chloride breaks down conjunctival immunological tolerance in a murine model; Nature Publishing Group; Mucosal Immunology; 6; 1; 6-2012; 24-34
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