Mostrar el registro sencillo del ítem
dc.contributor.author
Daray, Federico Manuel
dc.contributor.author
Rodante, Demián
dc.contributor.author
Carosella, Laura G.
dc.contributor.author
Silva, María Elena
dc.contributor.author
Martínez, Melina María Belén
dc.contributor.author
Busch, María V. Fernández
dc.contributor.author
Faccone, Diego Francisco
dc.contributor.author
Rothlin, Rodolfo Pedro
dc.contributor.author
Maffia, Paulo Cesar
dc.date.available
2018-07-27T18:16:58Z
dc.date.issued
2017-01
dc.identifier.citation
Daray, Federico Manuel; Rodante, Demián; Carosella, Laura G.; Silva, María Elena; Martínez, Melina María Belén; et al.; -759C > T polymorphism of the HTR2C gene is associated with second generation antipsychotic-induced weight gain in female patients with schizophrenia; Georg Thieme Verlag Kg; Pharmacopsychiatry.; 50; 1; 1-2017; 14-18
dc.identifier.issn
0176-3679
dc.identifier.uri
http://hdl.handle.net/11336/53311
dc.description.abstract
Introduction: The HTR2C gene is an important candidate in pharmacogenetic studies of antipsychotic-induced weight gain (AIWG). However, inconsistent results have been obtained. The present study investigated the association between -759C > T, functional polymorphism of the HTR2C receptor, and AIWG. Methods: A prospective cohort of 48 female inpatients with schizophrenia and related illness treated according to normal clinical practice with second generation antipsychotics (SGAs) risperidone, clozapine, quetiapine, and olanzapine were evaluated. Patients were weighted at admission and again at 6 weeks of hospitalization. Weight gain was defined as an increase ≥ 7 % of baseline weight. The association between polymorphisms HTR2C and weight gain was evaluated. Multiple logistic regression was run to determine potential confounders. Results: Patients with the T allele at position -759 (TT or CT) gained less weight as compared to patients who did not have the allele. This association was not affected by possible confounding factors such as age, baseline BMI, and prior psychopharmacological treatment. Discussion: The T allele at position -759 protects against AIWG in female patients with schizophrenia.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Georg Thieme Verlag Kg
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Second Generation Antipsychotic
dc.subject
Weight Gain
dc.subject
Htr2c Gene
dc.subject
Schizophrenia
dc.subject
Weight Gain
dc.subject.classification
Medicina Critica y de Emergencia
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
-759C > T polymorphism of the HTR2C gene is associated with second generation antipsychotic-induced weight gain in female patients with schizophrenia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-25T13:55:20Z
dc.journal.volume
50
dc.journal.number
1
dc.journal.pagination
14-18
dc.journal.pais
Alemania
dc.journal.ciudad
Stuttgart
dc.description.fil
Fil: Daray, Federico Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Rodante, Demián. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Hospital “Braulio A. Moyano”; Argentina
dc.description.fil
Fil: Carosella, Laura G.. Hospital “Braulio A. Moyano”; Argentina
dc.description.fil
Fil: Silva, María Elena. Hospital “Braulio A. Moyano”; Argentina
dc.description.fil
Fil: Martínez, Melina María Belén. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Microbiología Molecular; Argentina
dc.description.fil
Fil: Busch, María V. Fernández. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Microbiología Molecular; Argentina
dc.description.fil
Fil: Faccone, Diego Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Microbiología Molecular; Argentina
dc.description.fil
Fil: Rothlin, Rodolfo Pedro. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Maffia, Paulo Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Microbiología Molecular; Argentina
dc.journal.title
Pharmacopsychiatry.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1055/s-0042-110321
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-110321
Archivos asociados