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dc.contributor.author
Bessone, Fernando
dc.contributor.author
Hernandez, Nelia
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Roma, Marcelo Gabriel
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Ridruejo, Ezequiel
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Mendizabal, Manuel
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Medina Cáliz, Inmaculada
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Robles Díaz, Mercedes
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Lucena, M. Isabel
dc.contributor.author
Andrade, Raúl J.
dc.date.available
2018-07-27T15:09:20Z
dc.date.issued
2016-11
dc.identifier.citation
Bessone, Fernando; Hernandez, Nelia; Roma, Marcelo Gabriel; Ridruejo, Ezequiel; Mendizabal, Manuel; et al.; Hepatotoxicity induced by coxibs: how concerned should we be?; Informa Healthcare; Expert Opinion On Drug Safety; 15; 11; 11-2016; 1463-1475
dc.identifier.issn
1474-0338
dc.identifier.uri
http://hdl.handle.net/11336/53297
dc.description.abstract
Introduction: The selective inhibitors of COX-2, coxibs, are nonsteroidal anti-inflammatory drugs (NSAIDs) that have much better gastrointestinal safety profile as compared with non-selective NSAIDs. In this review, we analyze both the epidemiological features of coxib-induced hepatotoxicity and the clinical impact of coxib-associated liver damage, based on literature data. Areas covered: We carried out a search of the databases MEDLINE (PubMed), LILACS and SCIELO, from December 1999 to January 2016, to retrieve studies exploring the real impact of coxibs in liver toxicity as compared to non-selective COX-2 inhibitor NSAIDs. Expert opinion: Although reliable data on the incidence of celecoxib- and etoricoxib-induced hepatotoxicity are lacking, because of cohort studies have been generally underpowered to detect hepatic events, coxibs have been scarcely related to hepatotoxicity. Hence, coxib-induced liver injury seems to be an uncommon event, yet exhibits a wide spectrum of damage. Increasing COX-2 drug selectivity, as for rofecoxib, valdecoxib, parecoxib, and lumiracoxib, has been associated with higher cardiovascular risk, as well as dermatological and serious hepatic reactions. The actual risk of liver toxicity from the currently approved coxibs compared with non-selective NSAIDs will be discussed. Finally, classical and novel molecular mechanisms of coxib-induced hepatotoxicity are also described.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Informa Healthcare
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Acute Liver Failure
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Cholestasis
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Coxibs
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Hepatitis
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Hepatotoxicity
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Selective Cox-2 Inhibitors
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Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Hepatotoxicity induced by coxibs: how concerned should we be?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-23T12:55:42Z
dc.journal.volume
15
dc.journal.number
11
dc.journal.pagination
1463-1475
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Bessone, Fernando. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
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Fil: Hernandez, Nelia. Universidad de la República; Uruguay
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Fil: Roma, Marcelo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
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Fil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
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Fil: Mendizabal, Manuel. Hospital Universitario Austral; Argentina
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Fil: Medina Cáliz, Inmaculada. Universidad de Málaga; España
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Fil: Robles Díaz, Mercedes. Universidad de Málaga; España
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Fil: Lucena, M. Isabel. Universidad de Málaga; España
dc.description.fil
Fil: Andrade, Raúl J.. Universidad de Málaga; España
dc.journal.title
Expert Opinion On Drug Safety
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1080/14740338.2016.1225719
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/14740338.2016.1225719
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