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Artículo

Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis

D'agostino, Liliana Elena; Ventimiglia, Fernando; Verna, Juan Antonio; de la Colina, Amelia; Aguirre, Yanina; Arturi, Alfredo; Capparelli, Alberto LuisIcon
Fecha de publicación: 02/2013
Editorial: Taylor & Francis
Revista: Autoimmunity
ISSN: 0891-6934
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Físico-Química, Ciencia de los Polímeros, Electroquímica; Bioquímica y Biología Molecular; Reumatología

Resumen

Objective: The objective of this study was to evaluate neopterin plasma concentrations in patients with early Rheumatoid Arthritis (RA) and correlate them with disease activity. Methods: This is a 28-month prospective study carried out on 65 individuals. There were 27 patients with early RA and 38 healthy volunteers as control group. Enzyme immunoassay was used to measure concentrations of neopterin and anti-cyclic citrullinated peptide (CCP) antibodies. Rheumatoid factor (RF) and C-reactive protein (CRP) were measured turbidimetrically, and antinuclear antibodies (ANA) were detected by immunofluorescence. Patients with early RA disease activity were divided into 4 groups according to DAS-28 criteria. Neopterin concentrations in RA patients were compared to conventional RA diagnostic serological markers. Results: Healthy volunteers had a mean neopterin concentration of 5.63 ^ 0.38 [1.36?9.93] nmol. L21. A statistically significant elevation of neopterin mean concentration was found on early RA patients: mean value of 8.92 ^ 0.93 [3.94?28.3] nmol. L21 ( p , 0.001). Pearson product moment correlation suggests a correlation between neopterin concentrations and DAS-28 (r ¼ 0.208, p ¼ 0.065). The analysis of the mean values grouped according with the DAS-28 criteria showed a correspondence between these means, with a Pearson correlation coefficient r ¼ 0.979, p ¼ 0.021. CRP concentrations also showed a similar trend. Anti-CCP antibodies and RF revealed a positive relationship with RA activity. Such a correlation was not found with ANA results. Conclusions: The elevation of plasma neopterin concentrations in early RA patients may indicate stimulation of immune response. Good correlation between neopterin concentrations and DAS-28 may facilitate assessing disease activity.
Palabras clave: Rheumatoid Arthritis , Immune Activation , Neopterin , Das-28 , Rheumatoid Factor , C-Reactive Protein
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/5329
DOI: http://dx.doi.org/ 10.3109/08916934.2012.722143
DOI: http://dx.doi.org/10.3109/08916934.2012.722143
URL: http://www.tandfonline.com/doi/abs/10.3109/08916934.2012.722143
Colecciones
Articulos(SEDE CENTRAL) [31608]
Articulos de SEDE CENTRAL
Articulos(INIFTA) [1246]
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Citación
D'agostino, Liliana Elena; Ventimiglia, Fernando; Verna, Juan Antonio; de la Colina, Amelia; Aguirre, Yanina; et al.; Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis; Taylor & Francis; Autoimmunity; 46; 1; 2-2013; 44-49
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