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dc.contributor.author
Cai, You-Sheng  
dc.contributor.author
Sarotti, Ariel Marcelo  
dc.contributor.author
Gündisch, Daniela  
dc.contributor.author
Kondratyuk, Tamara P.  
dc.contributor.author
Pezzuto, John  
dc.contributor.author
Turkson, James  
dc.contributor.author
Cao, Shugeng  
dc.date.available
2018-07-26T18:46:06Z  
dc.date.issued
2017-09  
dc.identifier.citation
Cai, You-Sheng; Sarotti, Ariel Marcelo; Gündisch, Daniela; Kondratyuk, Tamara P.; Pezzuto, John; et al.; Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 27; 20; 9-2017; 4630-4634  
dc.identifier.issn
0960-894X  
dc.identifier.uri
http://hdl.handle.net/11336/53189  
dc.description.abstract
Two new compounds heliotropiumides A (1) and B (2), phenolamides each with an uncommon carbamoyl putrescine moiety, were isolated from the seeds of a naturalized Hawaiian higher plant, Heliotropium foertherianum Diane & Hilger in the borage family, which is widely used for the treatment of ciguatera fish poisoning. The structures of compounds 1 and 2 were characterized based on MS spectroscopic and NMR analysis, and DP4+ calculations. The absolute configuration (AC) of compound 1 was determined by comparison of its optical rotation with those reported in literature. Compound 2 showed inhibition against NF-κB with an IC50 value of 36 μM.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Heliotropium Foertherianum  
dc.subject
Heliotropiumides  
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Nf-ΚB  
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Nmr Dp4+ Calculation  
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Optical Rotation  
dc.subject.classification
Otras Ciencias Químicas  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-07-26T14:01:21Z  
dc.journal.volume
27  
dc.journal.number
20  
dc.journal.pagination
4630-4634  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Hawai  
dc.description.fil
Fil: Cai, You-Sheng. University of Hawaii at Hilo; Estados Unidos. Wuhan University; China  
dc.description.fil
Fil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina  
dc.description.fil
Fil: Gündisch, Daniela. University of Hawaii at Hilo; Estados Unidos  
dc.description.fil
Fil: Kondratyuk, Tamara P.. University of Hawaii at Hilo; Estados Unidos  
dc.description.fil
Fil: Pezzuto, John. Long Island University; Estados Unidos. University of Hawaii Cancer Center; Estados Unidos  
dc.description.fil
Fil: Turkson, James. University of Hawaii Cancer Center; Estados Unidos  
dc.description.fil
Fil: Cao, Shugeng. University of Hawaii at Hilo; Estados Unidos  
dc.journal.title
Biorganic and Medicinal Chemistry Letters  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.bmcl.2017.09.021  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960894X17309162  

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