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dc.contributor.author
Capoulat, Maria Eugenia
dc.contributor.author
Kreiner, Andres Juan
dc.date.available
2018-07-25T18:53:47Z
dc.date.issued
2017-01
dc.identifier.citation
Capoulat, Maria Eugenia; Kreiner, Andres Juan; A 13C(d,n)-based epithermal neutron source for Boron Neutron Capture Therapy; Istituti Editoriali e Poligrafici Internazionali; Physica Medica; 33; 1-2017; 106-113
dc.identifier.issn
1120-1797
dc.identifier.uri
http://hdl.handle.net/11336/53119
dc.description.abstract
Purpose Boron Neutron Capture Therapy (BNCT) requires neutron sources suitable for in-hospital siting. Low-energy particle accelerators working in conjunction with a neutron producing reaction are the most appropriate choice for this purpose. One of the possible nuclear reactions is 13C(d,n)14N. The aim of this work is to evaluate the therapeutic capabilities of the neutron beam produced by this reaction, through a 30 mA beam of deuterons of 1.45 MeV. Methods A Beam Shaping Assembly design was computationally optimized. Depth dose profiles in a Snyder head phantom were simulated with the MCNP code for a number of BSA configurations. In order to optimize the treatment capabilities, the BSA configuration was determined as the one that allows maximizing both the tumor dose and the penetration depth while keeping doses to healthy tissues under the tolerance limits. Results Significant doses to tumor tissues were achieved up to ∼6 cm in depth. Peak doses up to 57 Gy-Eq can be delivered in a fractionated scheme of 2 irradiations of approximately 1 h each. In a single 1 h irradiation, lower but still acceptable doses to tumor are also feasible. Conclusions Treatment capabilities obtained here are comparable to those achieved with other accelerator-based neutron sources, making of the 13C(d,n)14N reaction a realistic option for producing therapeutic neutron beams through a low-energy particle accelerator.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Istituti Editoriali e Poligrafici Internazionali
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
13c(D,N)14n Reaction
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Accelerator-Based Bnct
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Brain Tumor Treatment
dc.subject
Epithermal Neutron Sources
dc.subject
Monte-Carlo-Simulations
dc.subject.classification
Astronomía
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Ciencias Físicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
A 13C(d,n)-based epithermal neutron source for Boron Neutron Capture Therapy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-25T13:55:05Z
dc.journal.volume
33
dc.journal.pagination
106-113
dc.journal.pais
Italia
dc.journal.ciudad
Roma
dc.description.fil
Fil: Capoulat, Maria Eugenia. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Kreiner, Andres Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
dc.journal.title
Physica Medica
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ejmp.2016.12.017
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1120179716311279
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