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dc.contributor.author
Capoulat, Maria Eugenia  
dc.contributor.author
Kreiner, Andres Juan  
dc.date.available
2018-07-25T18:53:47Z  
dc.date.issued
2017-01  
dc.identifier.citation
Capoulat, Maria Eugenia; Kreiner, Andres Juan; A 13C(d,n)-based epithermal neutron source for Boron Neutron Capture Therapy; Istituti Editoriali e Poligrafici Internazionali; Physica Medica; 33; 1-2017; 106-113  
dc.identifier.issn
1120-1797  
dc.identifier.uri
http://hdl.handle.net/11336/53119  
dc.description.abstract
Purpose Boron Neutron Capture Therapy (BNCT) requires neutron sources suitable for in-hospital siting. Low-energy particle accelerators working in conjunction with a neutron producing reaction are the most appropriate choice for this purpose. One of the possible nuclear reactions is 13C(d,n)14N. The aim of this work is to evaluate the therapeutic capabilities of the neutron beam produced by this reaction, through a 30 mA beam of deuterons of 1.45 MeV. Methods A Beam Shaping Assembly design was computationally optimized. Depth dose profiles in a Snyder head phantom were simulated with the MCNP code for a number of BSA configurations. In order to optimize the treatment capabilities, the BSA configuration was determined as the one that allows maximizing both the tumor dose and the penetration depth while keeping doses to healthy tissues under the tolerance limits. Results Significant doses to tumor tissues were achieved up to ∼6 cm in depth. Peak doses up to 57 Gy-Eq can be delivered in a fractionated scheme of 2 irradiations of approximately 1 h each. In a single 1 h irradiation, lower but still acceptable doses to tumor are also feasible. Conclusions Treatment capabilities obtained here are comparable to those achieved with other accelerator-based neutron sources, making of the 13C(d,n)14N reaction a realistic option for producing therapeutic neutron beams through a low-energy particle accelerator.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Istituti Editoriali e Poligrafici Internazionali  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
13c(D,N)14n Reaction  
dc.subject
Accelerator-Based Bnct  
dc.subject
Brain Tumor Treatment  
dc.subject
Epithermal Neutron Sources  
dc.subject
Monte-Carlo-Simulations  
dc.subject.classification
Astronomía  
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Ciencias Físicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
A 13C(d,n)-based epithermal neutron source for Boron Neutron Capture Therapy  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-07-25T13:55:05Z  
dc.journal.volume
33  
dc.journal.pagination
106-113  
dc.journal.pais
Italia  
dc.journal.ciudad
Roma  
dc.description.fil
Fil: Capoulat, Maria Eugenia. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Kreiner, Andres Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina  
dc.journal.title
Physica Medica  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ejmp.2016.12.017  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1120179716311279