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dc.contributor.author Garbus, Ingrid
dc.contributor.author Bouzat, Cecilia Beatriz
dc.contributor.author Barrantes, Francisco Jose
dc.date.available 2018-07-25T17:46:35Z
dc.date.issued 2001-12-02
dc.identifier.citation Garbus, Ingrid; Bouzat, Cecilia Beatriz; Barrantes, Francisco Jose; Steroids differentially inhibit the nicotinic acetylcholine receptor; Lippincott Williams; Neuroreport; 12; 2; 2-12-2001; 227-231
dc.identifier.issn 0959-4965
dc.identifier.uri http://hdl.handle.net/11336/53099
dc.description.abstract The effect of various natural and synthetic steroids on the function of the nicotinic acetylcholine receptor (AChR) was studied at the single-channel level. AChR channel kinetics was affected by some substitutions in the cyclopentaneperhydrophenantrene ring. Functionally relevant substitutions shortened channel open state duration, an effect that varied for different steroids. The presence of a polar group at C11 contributed to the inhibitory potency of the steroid. Among mono-hydroxy- lated steroids such as 11- and 17-OH progesterone, the highest potency was displayed by the former showing a level similar to that of the reference compound, hydrocortisone. When the effects were analyzed in terms of the octanol–water partition coefficient, a linear relationship was unexpectedly found between the hydrophilicity of the steroids and their inhibitory potency.
dc.format application/pdf
dc.language.iso eng
dc.publisher Lippincott Williams
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject CHANNEL BLOCKADE
dc.subject PATCH-CLAMP
dc.subject NICOTIC RECEPTOR
dc.subject STEROIDS
dc.subject.classification Otras Ciencias Biológicas
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Steroids differentially inhibit the nicotinic acetylcholine receptor
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-07-11T14:11:07Z
dc.journal.volume 12
dc.journal.number 2
dc.journal.pagination 227-231
dc.journal.pais Estados Unidos
dc.journal.ciudad Filadelfia
dc.description.fil Fil: Garbus, Ingrid. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil Fil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.journal.title Neuroreport
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/11209925
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/neuroreport/pages/articleviewer.aspx?year=2001&issue=02120&article=00010&type=abstract
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)