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dc.contributor.author
Garbus, Ingrid
dc.contributor.author
Bouzat, Cecilia Beatriz
dc.contributor.author
Barrantes, Francisco Jose
dc.date.available
2018-07-25T17:46:35Z
dc.date.issued
2001-12-02
dc.identifier.citation
Garbus, Ingrid; Bouzat, Cecilia Beatriz; Barrantes, Francisco Jose; Steroids differentially inhibit the nicotinic acetylcholine receptor; Lippincott Williams; Neuroreport; 12; 2; 2-12-2001; 227-231
dc.identifier.issn
0959-4965
dc.identifier.uri
http://hdl.handle.net/11336/53099
dc.description.abstract
The effect of various natural and synthetic steroids on the function of the nicotinic acetylcholine receptor (AChR) was studied at the single-channel level. AChR channel kinetics was affected by some substitutions in the cyclopentaneperhydrophenantrene ring. Functionally relevant substitutions shortened channel open state duration, an effect that varied for different steroids. The presence of a polar group at C11 contributed to the inhibitory potency of the steroid. Among mono-hydroxy- lated steroids such as 11- and 17-OH progesterone, the highest potency was displayed by the former showing a level similar to that of the reference compound, hydrocortisone. When the effects were analyzed in terms of the octanol–water partition coefficient, a linear relationship was unexpectedly found between the hydrophilicity of the steroids and their inhibitory potency.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Channel Blockade
dc.subject
Patch-Clamp
dc.subject
Nicotic Receptor
dc.subject
Steroids
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Steroids differentially inhibit the nicotinic acetylcholine receptor
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-11T14:11:07Z
dc.journal.volume
12
dc.journal.number
2
dc.journal.pagination
227-231
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Filadelfia
dc.description.fil
Fil: Garbus, Ingrid. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.journal.title
Neuroreport
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/11209925
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/neuroreport/pages/articleviewer.aspx?year=2001&issue=02120&article=00010&type=abstract


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