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dc.contributor.author
Farez, Mauricio Franco
dc.contributor.author
Calandri, Ismael L.
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Correale, Jorge
dc.contributor.author
Quintana, Francisco J.
dc.date.available
2018-07-25T16:54:22Z
dc.date.issued
2016-10
dc.identifier.citation
Farez, Mauricio Franco; Calandri, Ismael L.; Correale, Jorge; Quintana, Francisco J.; Anti-inflammatory effects of melatonin in multiple sclerosis; John Wiley & Sons Inc; Bioessays; 38; 10; 10-2016; 1016-1026
dc.identifier.issn
0265-9247
dc.identifier.uri
http://hdl.handle.net/11336/53086
dc.description.abstract
Melatonin is a hormone with complex roles in the pathogenesis of autoimmune disorders. Over the years, it has become clear that melatonin may exacerbate some autoimmune conditions, whereas it alleviates others such as multiple sclerosis. Multiple sclerosis is an autoimmune disorder characterized by a dysregulated immune response directed against the central nervous system. Indeed, the balance between pathogenic CD4+ T cells secreting IFN-γ (TH1) or IL-17 (TH17); and FoxP3+ regulatory T cells and IL-10+ type 1 regulatory T cells (Tr1 cells) is thought to play an important role in disease activity. Recent evidence suggests that melatonin ameliorates multiple sclerosis by controlling the balance between effector and regulatory cells, suggesting that melatonin-triggered signaling pathways are potential targets for therapeutic intervention. Here, we review the available data on the effects of melatonin on immune processes relevant for MS and discuss its therapeutic potential.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Melatonin
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Mtnr1a
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Multiple Sclerosis
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Ror-Α
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Th17 Cells
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Tr1 Regulatory Cells
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Anti-inflammatory effects of melatonin in multiple sclerosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-25T13:56:54Z
dc.journal.volume
38
dc.journal.number
10
dc.journal.pagination
1016-1026
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Farez, Mauricio Franco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina
dc.description.fil
Fil: Calandri, Ismael L.. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina
dc.description.fil
Fil: Correale, Jorge. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina
dc.description.fil
Fil: Quintana, Francisco J.. Harvard Medical School; Estados Unidos. The Broad Institute; Estados Unidos
dc.journal.title
Bioessays
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/bies.201600018
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/bies.201600018
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