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dc.contributor.author
Humeau-Heurtier, Anne
dc.contributor.author
Colominas, Marcelo Alejandro
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dc.contributor.author
Schlotthauer, Gaston
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dc.contributor.author
Etienne, Maxime
dc.contributor.author
Martin, Ludovic
dc.contributor.author
Abraham, Pierre
dc.date.available
2018-07-25T15:37:06Z
dc.date.issued
2017-03
dc.identifier.citation
Humeau-Heurtier, Anne; Colominas, Marcelo Alejandro; Schlotthauer, Gaston; Etienne, Maxime; Martin, Ludovic; et al.; Bidimensional unconstrained optimization approach to EMD: An algorithm revealing skin perfusion alterations in pseudoxanthoma elasticum patients; Elsevier Ireland; Computer Methods And Programs In Biomedicine; 140; 3-2017; 233-239
dc.identifier.issn
0169-2607
dc.identifier.uri
http://hdl.handle.net/11336/53074
dc.description.abstract
Background and Objective: Pseudoxanthoma elasticum (PXE) is an inherited and systemic metabolic disorder that affects the skin, leading among other things to a peau d'orange appearance. Unfortunately, PXE is still poorly understood and there is no existing therapy to treat the disease. Because the skin is the first organ to be affected in PXE, we propose herein a study of skin microvascular perfusion. By means of this analysis, our goal is to increase knowledge of PXE. Methods: For this purpose, microvascular data from patients suffering from PXE and from healthy control subjects were recorded using the laser speckle contrast imaging (LSCI) modality. These data were processed using the recent 2D version of the unconstrained optimization approach to empirical mode decomposition (UOA-EMD). Our work therefore corresponds to the first time this algorithm has been applied to biomedical data. Results: Our study shows that the 2D-UOA-EMD is able to reveal spatial patterns on local textures of LSCI data. Moreover, these spatial patterns differ between PXE patients and control subjects. Quantification measure of these spatial patterns reveals statistical significant differences between PXE and control subjects, in the neck (p=0.0004) and in the back (p=0.0052). Conclusions: For the first time, alterations in microvascular perfusion in PXE patients have been revealed. Our findings open new avenues for our understanding of pathophysiologic skin changes in PXE.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Convex Optimization
dc.subject
Data-Driven Method
dc.subject
Empirical Mode Decomposition
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Laser Speckle Contrast Imaging
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Pseudoxanthoma Elasticum
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Time-Frequency
dc.subject.classification
Ingeniería de Sistemas y Comunicaciones
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dc.subject.classification
Ingeniería Eléctrica, Ingeniería Electrónica e Ingeniería de la Información
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Bidimensional unconstrained optimization approach to EMD: An algorithm revealing skin perfusion alterations in pseudoxanthoma elasticum patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-25T13:51:55Z
dc.journal.volume
140
dc.journal.pagination
233-239
dc.journal.pais
Irlanda
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dc.journal.ciudad
Limerick
dc.description.fil
Fil: Humeau-Heurtier, Anne. University of Angers; Francia
dc.description.fil
Fil: Colominas, Marcelo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
dc.description.fil
Fil: Schlotthauer, Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina. Centro de Investigación y Transferencia de Entre Ríos; Argentina
dc.description.fil
Fil: Etienne, Maxime. University of Angers; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Martin, Ludovic. University of Angers; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Abraham, Pierre. University of Angers; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia
dc.journal.title
Computer Methods And Programs In Biomedicine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.cmpb.2016.12.016
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0169260716307726
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