Mostrar el registro sencillo del ítem
dc.contributor.author
Rajendran, Arvind
dc.contributor.author
Inda, María Eugenia
dc.contributor.author
Bagam, Prathyusha
dc.contributor.author
Sahoo, Malaya K.
dc.contributor.author
Osorio, Diana
dc.contributor.author
Batra, Sanjay
dc.date.available
2018-07-25T12:57:55Z
dc.date.issued
2016-12
dc.identifier.citation
Rajendran, Arvind; Inda, María Eugenia; Bagam, Prathyusha; Sahoo, Malaya K.; Osorio, Diana; et al.; Transcription Factor NF-κB: An Update on Intervention Strategies; Birkhauser Verlag Ag; Archivum Immunologiae Et Therapiae Experimentalis; 64; 6; 12-2016; 463-483
dc.identifier.issn
0004-069X
dc.identifier.uri
http://hdl.handle.net/11336/53053
dc.description.abstract
The nuclear factor (NF)-κB family of transcription factors are ubiquitous and pleiotropic molecules that regulate the expression of more than 150 genes involved in a broad range of processes including inflammation, immunity, cell proliferation, differentiation, and survival. The chronic activation or dysregulation of NF-κB signaling is the central cause of pathogenesis in many disease conditions and, therefore, NF-κB is a major focus of therapeutic intervention. Because of this, understanding the relationship between NF-κB and the induction of various downstream signaling molecules is imperative. In this review, we provide an updated synopsis of the role of NF-κB in DNA repair and in various ailments including cardiovascular diseases, HIV infection, asthma, herpes simplex virus infection, chronic obstructive pulmonary disease, and cancer. Furthermore, we also discuss the specific targets for selective inhibitors and future therapeutic strategies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Birkhauser Verlag Ag
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Asthma
dc.subject
Cancer
dc.subject
Copd
dc.subject
Dna Damage
dc.subject
Hiv
dc.subject
Hsv
dc.subject
Nf-ΚB
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Transcription Factor NF-κB: An Update on Intervention Strategies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-23T12:55:32Z
dc.journal.volume
64
dc.journal.number
6
dc.journal.pagination
463-483
dc.journal.pais
Suiza
dc.journal.ciudad
BASEL
dc.description.fil
Fil: Rajendran, Arvind. Louisiana State University; Estados Unidos
dc.description.fil
Fil: Inda, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina
dc.description.fil
Fil: Bagam, Prathyusha. Southern University and A&M College; Estados Unidos
dc.description.fil
Fil: Sahoo, Malaya K.. Stanford University School of Medicine; Estados Unidos
dc.description.fil
Fil: Osorio, Diana. Louisiana State University; Estados Unidos
dc.description.fil
Fil: Batra, Sanjay. Louisiana State University; Estados Unidos. Southern University and A&M College; Estados Unidos
dc.journal.title
Archivum Immunologiae Et Therapiae Experimentalis
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/s00005-016-0405-y
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00005-016-0405-y
Archivos asociados