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dc.contributor.author
Salvador, Gabriela Alejandra
dc.contributor.author
Lopez, Federico M.
dc.contributor.author
Giusto, Norma Maria
dc.date.available
2018-07-24T19:10:58Z
dc.date.issued
2002-11-01
dc.identifier.citation
Salvador, Gabriela Alejandra; Lopez, Federico M.; Giusto, Norma Maria; Age-related changes in central nervous system phosphatidylserine decarboxylase activity; Wiley-liss, Div John Wiley & Sons Inc; Journal of Neuroscience Research; 70; 3; 1-11-2002; 283-289
dc.identifier.issn
0360-4012
dc.identifier.uri
http://hdl.handle.net/11336/52995
dc.description.abstract
A significant portion of brain phosphatidylethanolamine (PE) is synthesized by a pathway involving the mitochondrial enzyme phosphatidylserine decarboxylase (PSDC), in a process by which phosphatidylserine (PS) is transferred from the endoplasmic reticulum to mitochondria. Aging changes the fatty acid composition of brain phospholipids, PS and PE being the most affected. The present study was carried out to determine PSDC activity in cerebral cortex (CC) and cerebellum (CRBL) mitochondrial fraction from adult (4-month-old) and aged (30-month-old) rats and to compare these activities with that found in liver. To study the effect of 22:6n-3 content on the PSDC activity, PSs from different sources were prepared: rPS (from bovine retina, containing 36 mol % of 22:6n-3); adPS (from adult rat CC microsomal membranes, with 25 mole % 22:6n-3 content) and agPS (from aged rat CC microsomal membranes, with 21 mole % 22:6n-3 content). For aged CC PSDC, the preferred substrate was agPS (the physiological substrate for aged animals), whereas in adult CC PSDC the substrate preference was inverse (rPS > adPS > agPS). Furthermore, CRBL PSDC does not show any substrate preference based on 22:6n-3 content. CRBL PSDC activity in aged membranes using agPS as substrate is lower than PSDC activity in adult membranes in the presence of adPS. These results indicate that under physiological conditions, cerebellar PSDC is inhibited during aging. Liver PSDC activity showed the same substrate preference in adult and aged rats as adult CC PSDC. These findings lead us to conclude that PSDC activity has a differential tissue-dependent substrate preference characteristic of the aging process.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Psdc
dc.subject
Phosphotidylserine
dc.subject
Aging
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Age-related changes in central nervous system phosphatidylserine decarboxylase activity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-11T14:03:17Z
dc.identifier.eissn
1097-4547
dc.journal.volume
70
dc.journal.number
3
dc.journal.pagination
283-289
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Salvador, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Lopez, Federico M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Giusto, Norma Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.journal.title
Journal of Neuroscience Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jnr.10385
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jnr.10385


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