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dc.contributor.author Ruggiero, Raul Alejandro
dc.contributor.author Bruzzo Iraola, Juan
dc.contributor.author Chiarella, Paula
dc.contributor.author Bustuoabad, Oscar David
dc.contributor.author Meiss, Roberto P.
dc.contributor.author Pasqualini, Christiane D.
dc.date.available 2018-07-24T14:30:47Z
dc.date.issued 2012-03
dc.identifier.citation Ruggiero, Raul Alejandro; Bruzzo Iraola, Juan; Chiarella, Paula; Bustuoabad, Oscar David; Meiss, Roberto P.; et al.; Concomitant tumor resistance: The role of tyrosine isomers in the mechanisms of metastases control; American Association for Cancer Research; Cancer Research; 72; 5; 3-2012; 1043-1050
dc.identifier.issn 0008-5472
dc.identifier.uri http://hdl.handle.net/11336/52949
dc.description.abstract Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. Although previous studies indicated that T-cell-dependent processes mediate CR in hosts bearing immunogenic small tumors, manifestations of CR induced by immunogenic and nonimmunogenic large tumors have been associated with an elusive serum factor. In a recently published study, we identified this factor as meta-tyrosine and ortho-tyrosine, 2 isomers of tyrosine that would not be present in normal proteins. In 3 different murine models of cancer that generate CR, both meta- and orthotyrosine inhibited tumor growth. Additionally, we showed that both isoforms of tyrosine blocked metastasis in a fourth model that does not generate CR but is sensitive to CR induced by other tumors. Mechanistic studies showed that the antitumor effects of the tyrosine isomers were mediated in part by early inhibition of the MAP/ERK pathway and inactivation of STAT3, potentially driving tumor cells into a state of dormancy in G 0-phase. Other mechanisms, putatively involving the activation of an intra-S-phase checkpoint, would also inhibit tumor proliferation by accumulating cells in S-phase. By revealing a molecular basis for the classical phenomenon of CR, our findings may stimulate new generalized approaches to limit the development of metastases that arise after resection of primary tumors or after other stressors that may promote the escape of metastases from dormancy, an issue that is of pivotal importance to oncologists and their patients. ©2012 AACR.
dc.format application/pdf
dc.language.iso eng
dc.publisher American Association for Cancer Research
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject TYROSINE ISOMERS
dc.subject METASTASES CONTROL
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Concomitant tumor resistance: The role of tyrosine isomers in the mechanisms of metastases control
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-07-17T20:49:21Z
dc.journal.volume 72
dc.journal.number 5
dc.journal.pagination 1043-1050
dc.journal.pais Estados Unidos
dc.journal.ciudad Philadelphia
dc.description.fil Fil: Ruggiero, Raul Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Bruzzo Iraola, Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Chiarella, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Bustuoabad, Oscar David. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Meiss, Roberto P.. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil Fil: Pasqualini, Christiane D.. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.journal.title Cancer Research
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1158/0008-5472.CAN-11-2964
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://cancerres.aacrjournals.org/content/72/5/1043
dc.conicet.fuente individual


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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)