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dc.contributor.author
Behler, Friederike
dc.contributor.author
Steinwede, Kathrin
dc.contributor.author
Balboa, Luciana
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Ueberberg, Bianca
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Maus, Regina
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Kirchhof, Gabriele
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Yamasaki, Sho
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Welte, Tobias
dc.contributor.author
Maus, Ulrich A.
dc.date.available
2018-07-24T14:30:41Z
dc.date.issued
2012-09
dc.identifier.citation
Behler, Friederike; Steinwede, Kathrin; Balboa, Luciana; Ueberberg, Bianca; Maus, Regina; et al.; Role of mincle in alveolar macrophage-dependent innate immunity against mycobacterial infections in mice; American Association of Immunologists; Journal of Immunology; 189; 6; 9-2012; 3121-3129
dc.identifier.issn
0022-1767
dc.identifier.uri
http://hdl.handle.net/11336/52948
dc.description.abstract
The role of macrophage-inducible C-type lectin Mincle in lung innate immunity against mycobacterial infection is incompletely defined. In this study, we show that wild-type (WT) mice responded with a delayed Mincle induction on resident alveolar macrophages and newly immigrating exudate macrophages to infection with Mycobacterium bovis bacillus Calmette-Guérin (BCG), peaking by days 14-21 posttreatment. As compared with WT mice, Mincle knockout (KO) mice exhibited decreased proinflammatory mediator responses and leukocyte recruitment upon M. bovis BCG challenge, and they demonstrated increased mycobacterial loads in pulmonary and extrapulmonary organ systems. Secondary mycobacterial infection on day 14 after primary BCG challenge led to increased cytokine gene expression in sorted alveolar macrophages of WT mice, but not Mincle KO mice, resulting in substantially reduced alveolar neutrophil recruitment and increased mycobacterial loads in the lungs of Mincle KO mice. Collectively, these data show that WT mice respond with a relatively late Mincle expression on lung sentinel cells to M. bovis BCG infection. Moreover, M. bovis BCG-induced upregulation of C-type lectin Mincle on professional phagocytes critically shapes antimycobacterial responses in both pulmonary and extrapulmonary organ systems of mice, which may be important for elucidating the role of Mincle in the control of mycobacterial dissemination in mice. Copyright © 2012 by The American Association of Immunologists, Inc.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Association of Immunologists
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mincle
dc.subject
Bcg
dc.subject
Macrophages
dc.subject.classification
Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Role of mincle in alveolar macrophage-dependent innate immunity against mycobacterial infections in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-17T20:49:01Z
dc.journal.volume
189
dc.journal.number
6
dc.journal.pagination
3121-3129
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Bethesda
dc.description.fil
Fil: Behler, Friederike. Hannover Medical School; Alemania
dc.description.fil
Fil: Steinwede, Kathrin. Hannover Medical School; Alemania
dc.description.fil
Fil: Balboa, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Ueberberg, Bianca. Hannover Medical School; Alemania
dc.description.fil
Fil: Maus, Regina. Hannover Medical School; Alemania
dc.description.fil
Fil: Kirchhof, Gabriele. Hannover Medical School; Alemania
dc.description.fil
Fil: Yamasaki, Sho. Kyushu University; Japón
dc.description.fil
Fil: Welte, Tobias. Hannover Medical School; Alemania
dc.description.fil
Fil: Maus, Ulrich A.. Hannover Medical School; Alemania
dc.journal.title
Journal of Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.4049/jimmunol.1201399
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jimmunol.org/content/189/6/3121
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