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Artículo

Biphasic effect of a primary tumor on the growth of secondary tumor implants

Bruzzo Iraola, JuanIcon ; Chiarella, PaulaIcon ; Meissl, Roberto Jose; Ruggiero, Raul AlejandroIcon
Fecha de publicación: 10/2010
Editorial: Springer
Revista: Journal Of Cancer Research And Clinical Oncology
ISSN: 0171-5216
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Medicina Básica

Resumen

Background: The phenomenon of hormesis is characterized by a biphasic dose-response, exhibiting opposite effects in the low- and high-dose zones. In this study, we explored the possibility that the hormesis concept may describe the interactions between two tumors implanted in a single mouse, such that the resulting tumors are of different sizes. Materials and methods: We used two murine tumors of spontaneous origin and undetectable immunogenicity growing in BALB/c mice. A measure of cell proliferation was obtained by immunostaining for Ki-67 protein and by using the [3H] thymidine uptake assay. For serum fractionation, we utilized dialysis and chromatography on Sephadex G-15. Results: The larger primary tumor induced inhibitory or stimulatory effects on the growth of the smaller secondary one, depending on the ratio between the mass of the larger tumor relative to that of the smaller one, with high ratios rendering inhibition and low ratios inducing stimulation of the secondary tumor. Conclusion: Since metastases can be considered as natural secondary tumor implants in a tumor-bearing host and that they constitute the main problem in cancer pathology, the use of the concept of hormesis to describe those biphasic effects might have significant clinical implications. In effect, if the tumor-bearing host were placed in the inhibitory window, tumor extirpation could enhance the growth of distant metastases and, reciprocally, if placed in the stimulatory window, tumor extirpation would result not only in a reduction or elimination of primary tumor load but also in a slower growth or inhibition of metastases. © 2010 Springer-Verlag.
Palabras clave: Biphasic Dose-Response , Hormesis , Metastases , Murine Tumors , Secondary Tumor Implants
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/52934
DOI: https://dx.doi.org/10.1007/s00432-010-0818-7
URL: https://link.springer.com/article/10.1007%2Fs00432-010-0818-7
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Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Bruzzo Iraola, Juan; Chiarella, Paula; Meissl, Roberto Jose; Ruggiero, Raul Alejandro; Biphasic effect of a primary tumor on the growth of secondary tumor implants; Springer; Journal Of Cancer Research And Clinical Oncology; 136; 10; 10-2010; 1605-1615
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