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dc.contributor.author
Fariña, Juan Pablo
dc.contributor.author
Garcia, Maria Elisa
dc.contributor.author
Alzamendi, Ana
dc.contributor.author
Giovambattista, Andres
dc.contributor.author
Marra, Carlos Alberto
dc.contributor.author
Spinedi, Eduardo Julio
dc.contributor.author
Gagliardino, Juan Jose
dc.date.available
2016-04-19T19:57:23Z
dc.date.issued
2013-02
dc.identifier.citation
Fariña, Juan Pablo; Garcia, Maria Elisa; Alzamendi, Ana; Giovambattista, Andres; Marra, Carlos Alberto; et al.; Antioxidant treatment prevents the development of fructose-induced abdominal adipose tissue dysfunction; Portland Press; Clinical Science; 125; 2; 2-2013; 87-97
dc.identifier.issn
0143-5221
dc.identifier.uri
http://hdl.handle.net/11336/5292
dc.description.abstract
In the present study, we tested the effect of OS (oxidative stress) inhibition in rats fed on an FRD [fructose-rich diet; 10% (w/v) in drinking water] for 3 weeks. Normal adult male rats received a standard CD (commercial diet) or an FRD without or with an inhibitor of NADPH oxidase, APO (apocynin; 5 mM in drinking water; CD-APO and FRD-APO). We thereafter measured plasma OS and metabolic-endocrine markers, AAT (abdominal adipose tissue) mass and cell size, FA (fatty acid) composition (content and release), OS status, LEP (leptin) and IRS (insulin receptor substrate)-1/IRS-2 mRNAs, ROS (reactive oxygen species) production, NADPH oxidase activity and LEP release by isolated AAT adipocytes. FRD-fed rats had larger AAT mass without changes in body weight, and higher plasma levels of TAG (triacylglycerol), FAs, TBARS (thiobarbituric acid-reactive substance) and LEP. Although no significant changes in glucose and insulin plasma levels were observed in these animals, their HOMA-IR (homoeostasis model assessment of insulin resistance) values were significantly higher than those of CD. The AAT from FRD-fed rats had larger adipocytes, higher saturated FA content, higher NADPH oxidase activity, greater ROS production, a distorted FA content/release pattern, lower insulin sensitivity together with higher and lower mRNA content of LEP and IRS-1-/2 respectively, and released a larger amount of LEP. The development of all the clinical, OS, metabolic, endocrine and molecular changes induced by the FRD were significantly prevented by APO co-administration. The fact that APO treatment prevented both changes in NADPH oxidase activity and the development of all the FRD-induced AAT dysfunctions in normal rats strongly suggests that OS plays an important role in the FRD-induced MS (metabolic syndrome) phenotype.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Portland Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Adipokines
dc.subject
Abdominal Adipocytes
dc.subject
Lipid Metabolism
dc.subject
Insulin Signaling
dc.subject.classification
Medicina General e Interna
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Antioxidant treatment prevents the development of fructose-induced abdominal adipose tissue dysfunction
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-05-06 15:52:43.262787-03
dc.journal.volume
125
dc.journal.number
2
dc.journal.pagination
87-97
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Fariña, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico La Plata. Centro de Endocrinologia Experimental y Aplicada (i); Argentina
dc.description.fil
Fil: Garcia, Maria Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico La Plata. Centro de Endocrinologia Experimental y Aplicada (i); Argentina
dc.description.fil
Fil: Alzamendi, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto Multidisciplinario de Biología Celular (i); Argentina
dc.description.fil
Fil: Giovambattista, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto Multidisciplinario de Biología Celular (i); Argentina
dc.description.fil
Fil: Marra, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Bioquímicas de La Plata; Argentina
dc.description.fil
Fil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto Multidisciplinario de Biología Celular (i); Argentina
dc.description.fil
Fil: Gagliardino, Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico La Plata. Centro de Endocrinologia Experimental y Aplicada (i); Argentina
dc.journal.title
Clinical Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.clinsci.org/content/125/2/87
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1042/CS20120470
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1042/CS20120470
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