Artículo
Identification of galectins as novel regulators of platelet signaling and function
Romaniuk, María Albertina
; Negrotto, Soledad
; Campetella, Oscar Eduardo
; Rabinovich, Gabriel Adrián
; Schattner, Mirta Ana
Fecha de publicación:
07/2011
Editorial:
John Wiley & Sons Inc
Revista:
IUBMB Life
ISSN:
1521-6543
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug. Activation of platelets is therefore crucial for normal hemostasis. However, uncontrolled platelet activation may also lead to the formation of occlusive thrombi that can cause ischemic events. Platelets can be activated by soluble molecules including thrombin, TXA 2, adenosine diphosphate (ADP), and serotonin or by adhesive extracellular matrix (ECM) proteins such as von Willebrand factor and collagen. In this article, we review recent advances on the role of galectins in platelet physiology. By acting in either soluble or immobilized form, these glycan-binding proteins trigger platelet activation through modulation of discrete signaling pathways. We also offer new hypotheses and some speculations about the role of platelet-galectin interactions not only in hemostasis and thrombosis but also in inflammation and related diseases such as atherosclerosis and cancer. © 2011 IUBMB.
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Romaniuk, María Albertina; Negrotto, Soledad; Campetella, Oscar Eduardo; Rabinovich, Gabriel Adrián; Schattner, Mirta Ana; Identification of galectins as novel regulators of platelet signaling and function; John Wiley & Sons Inc; IUBMB Life; 63; 7; 7-2011; 521-527
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