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dc.contributor.author
Hindie, Elif
dc.contributor.author
Zanotti Fregonara, Paolo
dc.contributor.author
Quinto, Michele Arcangelo
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dc.contributor.author
Morgat, Clément
dc.contributor.author
Champion, Christophe
dc.date.available
2018-07-23T19:43:01Z
dc.date.issued
2016-05
dc.identifier.citation
Hindie, Elif; Zanotti Fregonara, Paolo; Quinto, Michele Arcangelo; Morgat, Clément; Champion, Christophe; Dose deposits from 90Y, 177Lu, 111In, and 161Tb in micrometastases of various sizes: Implications for radiopharmaceutical therapy; Society of Nuclear Medicine and Molecular Imaging; Journal of Nuclear Medicine; 57; 5; 5-2016; 759-764
dc.identifier.issn
0161-5505
dc.identifier.uri
http://hdl.handle.net/11336/52884
dc.description.abstract
Radiopharmaceutical therapy, traditionally limited to refractory metastatic cancer, is being increasingly used at earlier stages, such as for treating minimal residual disease. The aim of this study was to compare the effectiveness of90Y,177Lu,111In, and161Tb at irradiating micrometastases.90Y and177Lu are widely used β--emitting radionuclides.161Tb is a medium-energy β-radionuclide that is similar to177Lu but emits a higher percentage of conversion and Auger electrons.111In emits -photons and conversion and Auger electrons. Methods: We used the Monte Carlo code CELLDOSE to assess electron doses from a uniform distribution of90Y,177Lu,111In, or161Tb in spheres with diameters ranging from 10 mm to 10 m. Because these isotopes differ in electron energy per decay, the doses were compared assuming that 1 MeV was released per m3, which would result in 160 Gy if totally absorbed. Results: In a 10-mm sphere, the doses delivered by90Y,177Lu,111In, and161Tb were 96.5, 152, 153, and 152 Gy, respectively. The doses decreased along with the decrease in sphere size, and more abruptly so for90Y. In a 100- m metastasis, the dose delivered by90Y was only 1.36 Gy, compared with 24.5 Gy for177Lu, 38.9 Gy for111In, and 44.5 Gy for161Tb. In cell-sized spheres, the dose delivered by111In and161Tb was higher than that of177Lu. For instance, in a 10- m cell,177Lu delivered 3.92 Gy, compared with 22.8 Gy for111In and 14.1 Gy for161Tb. Conclusion:177Lu,111In, and161Tb might be more appropriate than90Y for treating minimal residual disease.161Tb is a promising radionuclide because it combines the advantages of a medium-energy β-emission with those of Auger electrons and emits fewer photons than111In. 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society of Nuclear Medicine and Molecular Imaging
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
111in
dc.subject
161tb
dc.subject
177lu
dc.subject
90y
dc.subject
Radiopharmaceutical Therapy
dc.subject.classification
Astronomía
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dc.subject.classification
Ciencias Físicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Dose deposits from 90Y, 177Lu, 111In, and 161Tb in micrometastases of various sizes: Implications for radiopharmaceutical therapy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-18T20:41:12Z
dc.journal.volume
57
dc.journal.number
5
dc.journal.pagination
759-764
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Reston
dc.description.fil
Fil: Hindie, Elif. Universite de Bordeaux; Francia
dc.description.fil
Fil: Zanotti Fregonara, Paolo. Universite de Bordeaux; Francia
dc.description.fil
Fil: Quinto, Michele Arcangelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universite de Bordeaux; Francia
dc.description.fil
Fil: Morgat, Clément. Universite de Bordeaux; Francia
dc.description.fil
Fil: Champion, Christophe. Universite de Bordeaux; Francia
dc.journal.title
Journal of Nuclear Medicine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://jnm.snmjournals.org/content/57/5/759
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2967/jnumed.115.170423
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