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dc.contributor.author Carestia, Agostina
dc.contributor.author Kaufman, Tomás
dc.contributor.author Schattner, Mirta Ana
dc.date.available 2018-07-20T20:36:29Z
dc.date.issued 2016-07
dc.identifier.citation Carestia, Agostina; Kaufman, Tomás; Schattner, Mirta Ana; Platelets: New bricks in the building of neutrophil extracellular traps; Frontiers Research Foundation; Frontiers in Immunology; 7; 271; 7-2016; 1-9
dc.identifier.issn 1663-4365
dc.identifier.uri http://hdl.handle.net/11336/52812
dc.description.abstract In addition to being key elements in hemostasis and thrombosis, platelets have an important role in the inflammatory and innate immune response. This activity is associated with their capability to recognize pathogens through the expression of toll-like receptors, the secretion of various cytokines, chemokines, and growth factors stored within their granules, and the expression of cell adhesion molecules that allows interaction with other immune cells, mainly neutrophils and monocytes. As part of the first line of defense, neutrophils control invading pathogens by phagocytosis, the release of antimicrobial proteins during degranulation, or through the formation of web-like structures named neutrophil extracellular traps (NETs). NETs are formed by chromatin, proteases, and antimicrobial proteins, and their main function is to trap and kill bacteria, virus, and fungi, avoiding their dissemination. Besides microorganisms, NET formation is also triggered by proinflammatory molecules and platelets. The uncontrolled formation of NETs might exert tissue damage and has been involved in a pathogenic mechanism of autoimmune and prothrombotic clinical conditions. In this review, we discuss the role of platelets in NET generation highlighting the mediators, stimuli, and molecular mechanisms involved in this phenomenon, both in human and murine models.
dc.format application/pdf
dc.language.iso eng
dc.publisher Frontiers Research Foundation
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject INFLAMMATION
dc.subject NEUTROPHIL EXTRACELLULAR TRAPS
dc.subject NEUTROPHILS
dc.subject PLATELET-NEUTROPHIL INTERACTION
dc.subject PLATELETS
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Platelets: New bricks in the building of neutrophil extracellular traps
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-07-17T20:50:11Z
dc.identifier.eissn 1664-3224
dc.journal.volume 7
dc.journal.number 271
dc.journal.pagination 1-9
dc.journal.pais Suiza
dc.journal.ciudad Lausanne
dc.description.fil Fil: Carestia, Agostina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Kaufman, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title Frontiers in Immunology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.3389/fimmu.2016.00271
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2016.00271/full
dc.conicet.fuente individual


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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)