Artículo

Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines

Giri, German FranciscoIcon ; Danielli, MauroIcon ; Marinelli, Raul AlbertoIcon ; Spanevello, Rolando AngelIcon
Fecha de publicación: 08/2016
Editorial: Pergamon-Elsevier Science Ltd
Revista: Biorganic and Medicinal Chemistry Letters
ISSN: 0960-894X
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

Levoglucosenone has been used as template for the synthesis of a wide variety of compounds with an impressive structural variability. However, scarce work has been done regarding the generation of new bioactive entities. Here we report the cytotoxic effect of levoglucosenone and some related derivatives against hepatocarcinoma cell lines. Compounds were obtained in only one synthetic step and one of them showed an activity within the range of IC50values of cisplatin, a frequently administered chemotherapy drug.
Palabras clave: Cancer Cell Lines , Cytotoxic Activity , Hepatocarcinoma , Levoglucosenone , Michael Addition
 
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/52667
URL: https://www.sciencedirect.com/science/article/pii/S0960894X16307090
DOI: http://dx.doi.org/10.1016/j.bmcl.2016.07.007
Colecciones
Articulos(IFISE) [149]
Articulos de INST.DE FISIOLOGIA EXPERIMENTAL (I)
Articulos(IQUIR) [499]
Articulos de INST.DE QUIMICA ROSARIO
Citación
Giri, German Francisco; Danielli, Mauro; Marinelli, Raul Alberto; Spanevello, Rolando Angel; Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 26; 16; 8-2016; 3955-3957
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