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dc.contributor.author Colli, Sandra
dc.contributor.author Furforo, Lilian
dc.contributor.author Rojo Pisarello, Eduardo
dc.contributor.author Maidana, Marcela
dc.contributor.author Martín, Carlos
dc.contributor.author Bordone, Javier
dc.contributor.author Slavutsky, Irma Rosa
dc.date.available 2018-07-18T19:33:08Z
dc.date.issued 2016-04
dc.identifier.citation Colli, Sandra; Furforo, Lilian; Rojo Pisarello, Eduardo; Maidana, Marcela; Martín, Carlos; et al.; A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient; Elsevier Inc; Cancer Genetics; 209; 4; 4-2016; 166-170
dc.identifier.issn 2210-7770
dc.identifier.uri http://hdl.handle.net/11336/52607
dc.description.abstract Translocation t(4;11)(q21;p15) is a rare recurrent change associated to T-cell acute leukemia. In most cases, this alteration appears as the only abnormality or as part of a simple karyotype. In this report, we present the first case of T acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) with the unbalanced translocation der(11)t(4;11)(q21;p15) as part of a very complex karyotype with multiple chromosome abnormalities, most of them not previously described in the literature. FISH (fluorescence in situ hybridization) and spectral karyotype (HiSKY) analysis confirmed the presence of complex alterations. The patient, a 16-year-old male, showed poor response to treatment and short survival (11 months). A detailed review of previously reported cases with t(4;11)(q21;p15) is also provided. The description of this type of alterations may contribute to the identification of new molecular mechanism associated to neoplastic development.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier Inc
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject CYTOGENETICS
dc.subject FISH
dc.subject SPECTRAL KARYOTYPE
dc.subject T-CELL ACUTE LEUKEMIA/LYMPHOMA
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-07-17T20:50:18Z
dc.journal.volume 209
dc.journal.number 4
dc.journal.pagination 166-170
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Colli, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: Furforo, Lilian. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Centro Nacional de Genética Médica; Argentina
dc.description.fil Fil: Rojo Pisarello, Eduardo. Hospital de Alta Complejidad “Presidente Juan Domingo Perón"; Argentina
dc.description.fil Fil: Maidana, Marcela. Hospital de Alta Complejidad “Presidente Juan Domingo Perón"; Argentina
dc.description.fil Fil: Martín, Carlos. Consultorio de Hematopatología; Argentina
dc.description.fil Fil: Bordone, Javier. Hospital de Alta Complejidad “Presidente Juan Domingo Perón"; Argentina
dc.description.fil Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title Cancer Genetics
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.cancergen.2016.01.001
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2210776216000144
dc.conicet.fuente individual


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)