Mostrar el registro sencillo del ítem
dc.contributor.author
Aris, Mariana
dc.contributor.author
Rodriguez Zubieta, Mariana
dc.contributor.author
Colombo, Marina
dc.contributor.author
Arriaga, Juan Martín
dc.contributor.author
Bianchini, Michele
dc.contributor.author
Alperovich, Myriam
dc.contributor.author
Bravo, Alicia I.
dc.contributor.author
Barrio, Maria Marcela
dc.contributor.author
Mordoh, Jose
dc.date.available
2018-07-18T15:40:53Z
dc.date.issued
2012-02
dc.identifier.citation
Aris, Mariana; Rodriguez Zubieta, Mariana; Colombo, Marina; Arriaga, Juan Martín; Bianchini, Michele; et al.; MART-1-and gp100-expressing and-non-expressing melanoma cells are equally proliferative in tumors and clonogenic in vitro; Williams & Wilkins; Journal Of Investigative Dermatology; 132; 2; 2-2012; 365-374
dc.identifier.issn
0022-202X
dc.identifier.uri
http://hdl.handle.net/11336/52562
dc.description.abstract
MART-1 and gp100 are prototypical melanoma antigen (Ag), but their clinical use as vaccines or as targets of cytotoxic lymphocytes achieved modest success. Possible explanations could be that as MART-1 and gp100 are melanocyte differentiation Ag, clonogenic Ag-non-expressing cells would be spared by immune effectors, or that clonogenic cells would be intrinsically resistant to cytotoxic lymphocytes. We therefore analyzed the proliferative status of MART-1/gp100-expressing and-non-expressing cells in biopsies, and the clonogenicity and sensitiveness to cytotoxic lymphocytes of the human cutaneous melanoma cell lines MEL-XY1 and MEL-XY3. Analysis of MART-1/gp100 and Ki-67 expression in 22 melanoma tumors revealed that MART-1/gp100-expressing and-non-expressing cells proliferated competitively. MART-1, gp100, tyrosinase, and CD271 expression were studied in MEL-XY1 and MEL-XY3 colonies. At 7 days, colonies displayed positive, negative, and mixed expression patterns. By 14 days, colonies of different sizes developed, showing cells with different clonogenic potential, and Ag were downregulated, suggesting Ag plasticity. Subcloning of MEL-XY1 colonies showed that Ag expression varied with time without interfering with clonogenicity. Finally, clonogenic, MART-1/gp100-expressing cells were lysed by specific CD8 lymphocytes. Thus, MART-1 and gp100 expression and plasticity would not interfere with proliferation or clonogenicity, and clonogenic cells may be lysed by cytotoxic lymphocytes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Williams & Wilkins
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Melanoma
dc.subject
Mart-1
dc.subject
Gp100
dc.subject
Clonogenicity
dc.subject
Antigen Plasticity
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
MART-1-and gp100-expressing and-non-expressing melanoma cells are equally proliferative in tumors and clonogenic in vitro
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-11T17:38:21Z
dc.identifier.eissn
1523-1747
dc.journal.volume
132
dc.journal.number
2
dc.journal.pagination
365-374
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Baltimore
dc.description.fil
Fil: Aris, Mariana. Instituto Alexander Fleming; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Rodriguez Zubieta, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Colombo, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Arriaga, Juan Martín. Instituto Alexander Fleming; Argentina
dc.description.fil
Fil: Bianchini, Michele. Instituto Alexander Fleming; Argentina
dc.description.fil
Fil: Alperovich, Myriam. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Bravo, Alicia I.. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
dc.description.fil
Fil: Barrio, Maria Marcela. Instituto Alexander Fleming; Argentina
dc.description.fil
Fil: Mordoh, Jose. Instituto Alexander Fleming; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.journal.title
Journal Of Investigative Dermatology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022202X15355858
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/jid.2011.312
Archivos asociados